Multi-target approach of Egyptian leek extract in ameliorating depressive-like behavior in rats exposed to chronic unpredictable mild stress

Multi-target approach of Egyptian leek extract in ameliorating depressive-like behavior in rats exposed to chronic unpredictable mild stress

IntroductionDepression is a widespread and debilitating disorder with a complex etiology involving oxidative stress, neuroinflammation, and apoptosis. Given the limitations of current treatments, there is an urgent need for alternative therapeutic approaches. This study evaluated the antidepressant...

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Bibliographic Details
Main Authors: Mai M. S. Mahmoud, Amina E. Essawy, Ahmed A. Soffar, Ahmed H. I. Faraag, Mohamed A. Dkhil, Omar A. Ahmed-Farid, Manal F. El-Khadragy, Ahmed E. Abdel Moniem
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Pharmacology
Subjects:
depression
Egyptian leek
chronic unexpected mild stress
oxidative stress
neuroinflammation
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1621762/full
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