Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI

Ghrelin-induced neuronal NPY promotes brain metastasis in lung cancer patients with low BMI

Abstract Obesity is a known risk factor for many cancers, yet recent studies reveal a paradoxical association between low body mass index (BMI) and increased brain metastasis in lung cancer—referred to as the “obesity paradox,” with unclear molecular mechanism(s). Here, we show a significantly highe...

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Bibliographic Details
Main Authors: Abhishek Tyagi, Shih-Ying Wu, Jee-Won Kim, Ravindra Pramod Deshpande, Kerui Wu, Eleanor C. Smith, Giuseppe L. Banna, Kounosuke Watabe
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60730-4
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