The effect of implicit learning on functional connectivity in schizophrenia
IntroductionNeuronal plasticity, or the ability to change and adapt in response to experiences, learning, or environment, is frequently disrupted in schizophrenia and contributes to disease-associated cognitive deficits and functional impairments.MethodsIn this study, we investigated the neuroplasti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1600449/full |
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| author | Asli Ceren Hinc Asli Ceren Hinc Simay Selek Ibrahim Sungur Ibrahim Sungur Kaan Keskin Kaan Keskin Furkan Yazici Furkan Yazici Mehmet Can Erata Mehmet Can Erata Yigit Erdogan Alpaslan Yilmaz Omer Kitis Mehmet Cagdas Eker Mehmet Cagdas Eker Ali Saffet Gonul Ali Saffet Gonul Ali Saffet Gonul |
| author_facet | Asli Ceren Hinc Asli Ceren Hinc Simay Selek Ibrahim Sungur Ibrahim Sungur Kaan Keskin Kaan Keskin Furkan Yazici Furkan Yazici Mehmet Can Erata Mehmet Can Erata Yigit Erdogan Alpaslan Yilmaz Omer Kitis Mehmet Cagdas Eker Mehmet Cagdas Eker Ali Saffet Gonul Ali Saffet Gonul Ali Saffet Gonul |
| author_sort | Asli Ceren Hinc |
| collection | DOAJ |
| description | IntroductionNeuronal plasticity, or the ability to change and adapt in response to experiences, learning, or environment, is frequently disrupted in schizophrenia and contributes to disease-associated cognitive deficits and functional impairments.MethodsIn this study, we investigated the neuroplasticity alterations of schizophrenia patients in the cortico-striato-cerebellar circuits associated with implicit learning using a reward-enhanced Serial Reaction Time Task (SRTT) by resting-state functional MRI (rs-fMRI). Forty-two schizophrenia patients and 25 healthy controls underwent pre- and post-task rs-fMRI to evaluate changes in functional connectivity.ResultsBehavioral results indicated that all participants demonstrated shorter reaction times during sequential blocks, schizophrenia patients exhibited lower accuracy suggesting diminished implicit learning. Schizophrenia patients exhibited increased connectivity across cortico-striatocerebellar circuits, which became even more robust and widespread following task completion. Despite impaired performance, this post-task hyperconnectivity may reflect a compensatory mechanism attempting to recruit additional neural resources—albeit in a dysfunctional or inefficient manner. Data-driven analyses confirmed the post-task differences between groups, identifying task-induced connectivity changes in thalamo-cortico-cerebellar circuits as the strongest predictors of a group membership.DiscussionThese findings underscore the role of neuroplasticity impairments in schizophrenia-related cognitive deficits, highlighting potential neural markers for clinical differentiation and paving the way for targeted interventions. |
| format | Article |
| id | doaj-art-8f6a5599511e4aef8bbc6d68d0539468 |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-8f6a5599511e4aef8bbc6d68d05394682025-08-20T03:31:21ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-06-011610.3389/fpsyt.2025.16004491600449The effect of implicit learning on functional connectivity in schizophreniaAsli Ceren Hinc0Asli Ceren Hinc1Simay Selek2Ibrahim Sungur3Ibrahim Sungur4Kaan Keskin5Kaan Keskin6Furkan Yazici7Furkan Yazici8Mehmet Can Erata9Mehmet Can Erata10Yigit Erdogan11Alpaslan Yilmaz12Omer Kitis13Mehmet Cagdas Eker14Mehmet Cagdas Eker15Ali Saffet Gonul16Ali Saffet Gonul17Ali Saffet Gonul18Standardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Psychiatry, Izmir City Hospital, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Psychiatry, Ege University, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Psychiatry, Ege University, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Psychiatry, Ege University, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Child and Adolescent Psychiatry, University of Health Sciences, Erenkoy Mental and Neurological Diseases Research, Istanbul, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeFaculty of Sport Sciences, Erciyes University, Kayseri, TürkiyeDepartment of Radiology, Ege University, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Psychiatry, Izmir City Hospital, Izmir, TürkiyeStandardization of Computational Anatomy Techniques for Cognitive and Behavioral Sciences (SoCAT) Lab, Department of Psychiatry, School of Medicine, Ege University, Izmir, TürkiyeDepartment of Psychiatry, Ege University, Izmir, TürkiyeDepartment of Psychiatry and Behavioral Sciences, Mercer University, School of Medicine, Mocon, GA, United StatesIntroductionNeuronal plasticity, or the ability to change and adapt in response to experiences, learning, or environment, is frequently disrupted in schizophrenia and contributes to disease-associated cognitive deficits and functional impairments.MethodsIn this study, we investigated the neuroplasticity alterations of schizophrenia patients in the cortico-striato-cerebellar circuits associated with implicit learning using a reward-enhanced Serial Reaction Time Task (SRTT) by resting-state functional MRI (rs-fMRI). Forty-two schizophrenia patients and 25 healthy controls underwent pre- and post-task rs-fMRI to evaluate changes in functional connectivity.ResultsBehavioral results indicated that all participants demonstrated shorter reaction times during sequential blocks, schizophrenia patients exhibited lower accuracy suggesting diminished implicit learning. Schizophrenia patients exhibited increased connectivity across cortico-striatocerebellar circuits, which became even more robust and widespread following task completion. Despite impaired performance, this post-task hyperconnectivity may reflect a compensatory mechanism attempting to recruit additional neural resources—albeit in a dysfunctional or inefficient manner. Data-driven analyses confirmed the post-task differences between groups, identifying task-induced connectivity changes in thalamo-cortico-cerebellar circuits as the strongest predictors of a group membership.DiscussionThese findings underscore the role of neuroplasticity impairments in schizophrenia-related cognitive deficits, highlighting potential neural markers for clinical differentiation and paving the way for targeted interventions.https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1600449/fullschizophrenianeuroplasticityserial reaction time taskfMRIimplicit learningneuroimaging |
| spellingShingle | Asli Ceren Hinc Asli Ceren Hinc Simay Selek Ibrahim Sungur Ibrahim Sungur Kaan Keskin Kaan Keskin Furkan Yazici Furkan Yazici Mehmet Can Erata Mehmet Can Erata Yigit Erdogan Alpaslan Yilmaz Omer Kitis Mehmet Cagdas Eker Mehmet Cagdas Eker Ali Saffet Gonul Ali Saffet Gonul Ali Saffet Gonul The effect of implicit learning on functional connectivity in schizophrenia Frontiers in Psychiatry schizophrenia neuroplasticity serial reaction time task fMRI implicit learning neuroimaging |
| title | The effect of implicit learning on functional connectivity in schizophrenia |
| title_full | The effect of implicit learning on functional connectivity in schizophrenia |
| title_fullStr | The effect of implicit learning on functional connectivity in schizophrenia |
| title_full_unstemmed | The effect of implicit learning on functional connectivity in schizophrenia |
| title_short | The effect of implicit learning on functional connectivity in schizophrenia |
| title_sort | effect of implicit learning on functional connectivity in schizophrenia |
| topic | schizophrenia neuroplasticity serial reaction time task fMRI implicit learning neuroimaging |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2025.1600449/full |
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