Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial
COVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. The severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to inves...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2021/2129006 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850211707895414784 |
|---|---|
| author | Mohammad Alsultan Ameer Obeid Omar Alsamarrai Mohamed Taher Anan Aliaa Bakr Nawwar Soliman Mamdoh Kurdy Muhannad Hag Mosa Zain Saleh Fatima Hujij Jafar Barhoum |
| author_facet | Mohammad Alsultan Ameer Obeid Omar Alsamarrai Mohamed Taher Anan Aliaa Bakr Nawwar Soliman Mamdoh Kurdy Muhannad Hag Mosa Zain Saleh Fatima Hujij Jafar Barhoum |
| author_sort | Mohammad Alsultan |
| collection | DOAJ |
| description | COVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. The severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to investigate the efficacy of two agents (oral colchicine and budesonide inhaler) in COVID-19 infection management, compared with supportive care alone. 77 patients were admitted to the isolation section of Al Assad University Hospital, between the 1st of August and the 30th of August. A total of 49 patients were included in this randomized control trial, after excluding ineligible patients. The random sample was divided into three groups; the first group was supportive care plus colchicine, the second group was supportive care plus budesonide inhaler, and the control group was supportive care alone. PaO2/FiO2 was improved in the budesonide group, higher than the supportive and colchicine groups. The median hospitalization days were shorter when using colchicine or budesonide, opposed to supportive care alone (8 vs 10 days, respectively). 34 patients (69.3%) were discharged, and 27 patients (55.1%) were followed up until they were weaned from oxygen and made a complete recovery. There was a significant decrease in mortality with colchicine (3 patients; 21.4%) compared with supportive care (7 patients; 33.3%) and the budesonide group (5 patients; 35.7%). |
| format | Article |
| id | doaj-art-8f626ae951674ca4b5bf578bfc101aa9 |
| institution | OA Journals |
| issn | 1687-7098 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-8f626ae951674ca4b5bf578bfc101aa92025-08-20T02:09:30ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-70982021-01-01202110.1155/2021/2129006Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control TrialMohammad Alsultan0Ameer Obeid1Omar Alsamarrai2Mohamed Taher Anan3Aliaa Bakr4Nawwar Soliman5Mamdoh Kurdy6Muhannad Hag Mosa7Zain Saleh8Fatima Hujij9Jafar Barhoum10Department of NephrologyDepartment of Infectious DiseasesDepartment of NeurologyProfessor, Statics DepartmentDepartment of OncologyDepartment of Internal MedicineDepartment of OncologyDepartment of Internal MedicineDepartment of NeurologyDepartment of Internal MedicineDepartment of RheumatologyCOVID-19 was reported in China in 2019 and has spread worldwide. Transmission occurs through respiratory secretions and, less commonly, through contaminated surfaces. The severity of the disease can range from asymptomatic to acute respiratory distress syndrome (ARDS). In this study, we aim to investigate the efficacy of two agents (oral colchicine and budesonide inhaler) in COVID-19 infection management, compared with supportive care alone. 77 patients were admitted to the isolation section of Al Assad University Hospital, between the 1st of August and the 30th of August. A total of 49 patients were included in this randomized control trial, after excluding ineligible patients. The random sample was divided into three groups; the first group was supportive care plus colchicine, the second group was supportive care plus budesonide inhaler, and the control group was supportive care alone. PaO2/FiO2 was improved in the budesonide group, higher than the supportive and colchicine groups. The median hospitalization days were shorter when using colchicine or budesonide, opposed to supportive care alone (8 vs 10 days, respectively). 34 patients (69.3%) were discharged, and 27 patients (55.1%) were followed up until they were weaned from oxygen and made a complete recovery. There was a significant decrease in mortality with colchicine (3 patients; 21.4%) compared with supportive care (7 patients; 33.3%) and the budesonide group (5 patients; 35.7%).http://dx.doi.org/10.1155/2021/2129006 |
| spellingShingle | Mohammad Alsultan Ameer Obeid Omar Alsamarrai Mohamed Taher Anan Aliaa Bakr Nawwar Soliman Mamdoh Kurdy Muhannad Hag Mosa Zain Saleh Fatima Hujij Jafar Barhoum Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial Interdisciplinary Perspectives on Infectious Diseases |
| title | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| title_full | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| title_fullStr | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| title_full_unstemmed | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| title_short | Efficacy of Colchicine and Budesonide in Improvement Outcomes of Patients with Coronavirus Infection 2019 in Damascus, Syria: A Randomized Control Trial |
| title_sort | efficacy of colchicine and budesonide in improvement outcomes of patients with coronavirus infection 2019 in damascus syria a randomized control trial |
| url | http://dx.doi.org/10.1155/2021/2129006 |
| work_keys_str_mv | AT mohammadalsultan efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT ameerobeid efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT omaralsamarrai efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT mohamedtaheranan efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT aliaabakr efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT nawwarsoliman efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT mamdohkurdy efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT muhannadhagmosa efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT zainsaleh efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT fatimahujij efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial AT jafarbarhoum efficacyofcolchicineandbudesonideinimprovementoutcomesofpatientswithcoronavirusinfection2019indamascussyriaarandomizedcontroltrial |