Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1
We report a case of non-Hodgkin’s lymphoma (NHL) with an unusual initial manifestation as severe hypercholesterolemia and obstructive jaundice in a patient with neurofibromatosis type 1 (NF 1). NHL should be considered in the evaluation of obstructive jaundice alone or in combination with severe hyp...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/579352 |
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| author | Kenechukwu Chudy-Onwugaje Nnaemeka Anyadike Yuriy Tsirlin Ira Mayer Rabin Rahmani |
| author_facet | Kenechukwu Chudy-Onwugaje Nnaemeka Anyadike Yuriy Tsirlin Ira Mayer Rabin Rahmani |
| author_sort | Kenechukwu Chudy-Onwugaje |
| collection | DOAJ |
| description | We report a case of non-Hodgkin’s lymphoma (NHL) with an unusual initial manifestation as severe hypercholesterolemia and obstructive jaundice in a patient with neurofibromatosis type 1 (NF 1). NHL should be considered in the evaluation of obstructive jaundice alone or in combination with severe hypercholesterolemia. Relief of biliary obstruction led to the resolution of hypercholesterolemia in our 59-year-old male patient, followed by doxorubicin-based chemotherapy for the underlying lymphoma. NF 1 is a genetic condition that results from a defect in a tumor-suppressor gene and it is likely that this led to the development of NHL in our patient. It is important that clinicians are familiar with the gastrointestinal manifestations of NF 1, especially its association with intra-abdominal malignancies, when treating patients with a personal or family history. To the best of our knowledge, this is the first case of NHL presenting initially as severe hypercholesterolemia and it is also one of the few instances where NHL has been reported in association with NF 1. |
| format | Article |
| id | doaj-art-8f6068e7b1d24ea6bdf5cf9c73436807 |
| institution | DOAJ |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-8f6068e7b1d24ea6bdf5cf9c734368072025-08-20T03:20:31ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362014-01-01201410.1155/2014/579352579352Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1Kenechukwu Chudy-Onwugaje0Nnaemeka Anyadike1Yuriy Tsirlin2Ira Mayer3Rabin Rahmani4Department of Internal Medicine, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11219, USADepartment of Gastroenterology, Maimonides Medical Center, Brooklyn, NY 11219, USAWe report a case of non-Hodgkin’s lymphoma (NHL) with an unusual initial manifestation as severe hypercholesterolemia and obstructive jaundice in a patient with neurofibromatosis type 1 (NF 1). NHL should be considered in the evaluation of obstructive jaundice alone or in combination with severe hypercholesterolemia. Relief of biliary obstruction led to the resolution of hypercholesterolemia in our 59-year-old male patient, followed by doxorubicin-based chemotherapy for the underlying lymphoma. NF 1 is a genetic condition that results from a defect in a tumor-suppressor gene and it is likely that this led to the development of NHL in our patient. It is important that clinicians are familiar with the gastrointestinal manifestations of NF 1, especially its association with intra-abdominal malignancies, when treating patients with a personal or family history. To the best of our knowledge, this is the first case of NHL presenting initially as severe hypercholesterolemia and it is also one of the few instances where NHL has been reported in association with NF 1.http://dx.doi.org/10.1155/2014/579352 |
| spellingShingle | Kenechukwu Chudy-Onwugaje Nnaemeka Anyadike Yuriy Tsirlin Ira Mayer Rabin Rahmani Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1 Case Reports in Gastrointestinal Medicine |
| title | Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1 |
| title_full | Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1 |
| title_fullStr | Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1 |
| title_full_unstemmed | Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1 |
| title_short | Severe Hypercholesterolemia: A Unique Presentation of Non-Hodgkin’s Lymphoma in a Patient with Neurofibromatosis Type 1 |
| title_sort | severe hypercholesterolemia a unique presentation of non hodgkin s lymphoma in a patient with neurofibromatosis type 1 |
| url | http://dx.doi.org/10.1155/2014/579352 |
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