New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2
Three new naphthalene–chroman dimer derivatives, daldinaphchromes A–C (<b>1</b>–<b>3</b>), two new chroman derivatives, daldichromes A (<b>5</b>) and B (<b>6</b>), along with five known compounds (<b>4</b>, <b>7</b>–<b>10&...
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MDPI AG
2025-05-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/23/6/238 |
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| author | Miao Yu Yikang Qiu Shiji Chen Jueying Shi Xiu Gong Jiayi Feng Fangru Lin Weinv Zeng Wenyuan Kang Caijuan Zheng Guolei Huang |
| author_facet | Miao Yu Yikang Qiu Shiji Chen Jueying Shi Xiu Gong Jiayi Feng Fangru Lin Weinv Zeng Wenyuan Kang Caijuan Zheng Guolei Huang |
| author_sort | Miao Yu |
| collection | DOAJ |
| description | Three new naphthalene–chroman dimer derivatives, daldinaphchromes A–C (<b>1</b>–<b>3</b>), two new chroman derivatives, daldichromes A (<b>5</b>) and B (<b>6</b>), along with five known compounds (<b>4</b>, <b>7</b>–<b>10</b>) were isolated from the mangrove-derived fungus <i>Daldinia eschscholzii</i> HJX1P2. Their structures and stereochemistries were elucidated through detailed NMR and MS analyses, calculated electronic circular dichroism, and comparison with previously reported data. Compound <b>1</b> demonstrated inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells, with an IC<sub>50</sub> value of 62.9 µM, and more effectively suppressed the expression of interleukin (IL)-6 than dexamethasone. A further mechanistic study suggested that <b>1</b> could prohibit the expression of iNOS in RAW 264.7 cells, and the molecular docking study suggested a possible interaction between <b>1</b> and the iNOS protein. Compounds <b>7</b> and <b>8</b> exhibited moderate to potent DPPH radical scavenging activity, with IC<sub>50</sub> values of 117.4 and 46.2 µM, respectively, compared with the positive control ascorbic acid (IC<sub>50</sub> = 45.6 µM). Compounds <b>4</b> and <b>10</b> showed ABTS<sup>+</sup> radical scavenging activity, with IC<sub>50</sub> values of 66.6 and 33.2 µM, respectively, which were equal to or lower than that of the positive control vitamin C (IC<sub>50</sub> = 59.7 µM). Compounds <b>1</b>–<b>3</b>, <b>7</b>, and <b>9</b> showed antibacterial activity against three <i>Staphylococcus aureus</i> strains, with MIC values of 74.4–390.6 μM. |
| format | Article |
| id | doaj-art-8f5de0c6e2f142cc953495c53c32afcf |
| institution | DOAJ |
| issn | 1660-3397 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj-art-8f5de0c6e2f142cc953495c53c32afcf2025-08-20T03:16:33ZengMDPI AGMarine Drugs1660-33972025-05-0123623810.3390/md23060238New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2Miao Yu0Yikang Qiu1Shiji Chen2Jueying Shi3Xiu Gong4Jiayi Feng5Fangru Lin6Weinv Zeng7Wenyuan Kang8Caijuan Zheng9Guolei Huang10Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaInternational Center for Aging and Cancer, Hainan Medical University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, ChinaThree new naphthalene–chroman dimer derivatives, daldinaphchromes A–C (<b>1</b>–<b>3</b>), two new chroman derivatives, daldichromes A (<b>5</b>) and B (<b>6</b>), along with five known compounds (<b>4</b>, <b>7</b>–<b>10</b>) were isolated from the mangrove-derived fungus <i>Daldinia eschscholzii</i> HJX1P2. Their structures and stereochemistries were elucidated through detailed NMR and MS analyses, calculated electronic circular dichroism, and comparison with previously reported data. Compound <b>1</b> demonstrated inhibitory effects on nitric oxide (NO) production in LPS-induced RAW 264.7 cells, with an IC<sub>50</sub> value of 62.9 µM, and more effectively suppressed the expression of interleukin (IL)-6 than dexamethasone. A further mechanistic study suggested that <b>1</b> could prohibit the expression of iNOS in RAW 264.7 cells, and the molecular docking study suggested a possible interaction between <b>1</b> and the iNOS protein. Compounds <b>7</b> and <b>8</b> exhibited moderate to potent DPPH radical scavenging activity, with IC<sub>50</sub> values of 117.4 and 46.2 µM, respectively, compared with the positive control ascorbic acid (IC<sub>50</sub> = 45.6 µM). Compounds <b>4</b> and <b>10</b> showed ABTS<sup>+</sup> radical scavenging activity, with IC<sub>50</sub> values of 66.6 and 33.2 µM, respectively, which were equal to or lower than that of the positive control vitamin C (IC<sub>50</sub> = 59.7 µM). Compounds <b>1</b>–<b>3</b>, <b>7</b>, and <b>9</b> showed antibacterial activity against three <i>Staphylococcus aureus</i> strains, with MIC values of 74.4–390.6 μM.https://www.mdpi.com/1660-3397/23/6/238naphthalene–chroman dimers<i>Daldinia eschscholzii</i>anti-inflammatory activityantioxidant activityanti-bacterial activity |
| spellingShingle | Miao Yu Yikang Qiu Shiji Chen Jueying Shi Xiu Gong Jiayi Feng Fangru Lin Weinv Zeng Wenyuan Kang Caijuan Zheng Guolei Huang New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 Marine Drugs naphthalene–chroman dimers <i>Daldinia eschscholzii</i> anti-inflammatory activity antioxidant activity anti-bacterial activity |
| title | New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 |
| title_full | New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 |
| title_fullStr | New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 |
| title_full_unstemmed | New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 |
| title_short | New Bioactive Polyketides from the Mangrove-Derived Fungus <i>Daldinia eschscholzii</i> HJX1P2 |
| title_sort | new bioactive polyketides from the mangrove derived fungus i daldinia eschscholzii i hjx1p2 |
| topic | naphthalene–chroman dimers <i>Daldinia eschscholzii</i> anti-inflammatory activity antioxidant activity anti-bacterial activity |
| url | https://www.mdpi.com/1660-3397/23/6/238 |
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