Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells

Inhibition of the Na+-glucose transporter SGLT2 reduces glucose uptake and IFNγ release from activated human CD4+ T cells

Glucose uptake in activated CD4+ T cells is essential for increased metabolic needs, synthesis of biomolecules and proliferation. Although, facilitated glucose transport is the predominant route for glucose entry at the time of activation, here we demonstrate role for the sodium-dependent glucose tr...

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Bibliographic Details
Main Authors: Zhe Jin, Hayma Hammoud, Amol K. Bhandage, Stasini Koreli, Azazul Islam Chowdhury, Peter Bergsten, Bryndis Birnir
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
glucose uptake
T cells
SGLT2
GLUT1
immunomodulation
IFNγ
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1576216/full
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