Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis

Low dose insulin infusion versus the standard dose in children with diabetic ketoacidosis: a meta-analysis

Aim: This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. Methods: We searched several databases, including PubMed, Embase, Scopus, Cochrane...

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Main Authors: Mohamed Mohamed Belal, Basma Badrawy Khalefa, Eslam Mohammed Rabea, Mazen Negmeldin Aly Yassin, Mohamed Nabih Bashir, Malak Mohamed Abd El-Hameed, Omar Elkoumi, Saad Mohamed Saad, Loubna Mohamed Saad, Mohamed Hamouda Elkasaby
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Future Science OA
Subjects:
diabetic ketoacidosis
DKA
insulin
low dose
pediatrics
standard dose
Online Access:https://www.tandfonline.com/doi/10.2144/fsoa-2023-0137
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Summary:Aim: This systematic review aims to consolidate findings from current clinical trials that compare the effectiveness of insulin infusion at 0.05 IU/kg/h versus 0.1 IU/kg/h in managing pediatric diabetic ketoacidosis. Methods: We searched several databases, including PubMed, Embase, Scopus, Cochrane Central and Web of Science. Our primary outcomes were time to reach blood glucose ≤250 mg/dl and time to resolution of acidosis. Secondary outcomes included rate of blood glucose decrease per hour, incidence of hypoglycemia, hypokalemia, treatment failure, and cerebral edema. Results & conclusion: The present study establishes that a low insulin dose exhibits comparable efficacy to the standard dosage for managing pediatric patients suffering from diabetic ketoacidosis, with a lower incidence of complications.
ISSN:2056-5623

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