A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue
Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. Objectives: The present study was carried out to assess the immunohistochemical expression of HER-2/neu protein and of silver binding nucleolar organizer regions in normal salivary tissue. Ma...
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| Format: | Article |
| Language: | English |
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Springer
2010-04-01
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| Series: | Saudi Dental Journal |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1013905210000209 |
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| author | Essam Taher M.A. Gaballah |
| author_facet | Essam Taher M.A. Gaballah |
| author_sort | Essam Taher M.A. Gaballah |
| collection | DOAJ |
| description | Salivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. Objectives: The present study was carried out to assess the immunohistochemical expression of HER-2/neu protein and of silver binding nucleolar organizer regions in normal salivary tissue. Materials and methods: Twenty paraffin blocks of salivary tumors containing surrounding normal salivary tissue were used in the study. One section was processed to investigate HER-2/neu protein expression and another section was stained to assess the mean Ag NOR counts in normal salivary tissue. Results: Only two cases of the studied normal salivary tissue showed HER-2/neu expression (10%), which was expressed only in ductal cells with 4.2 ± 2.1 mean number of reactive cells per five high power fields (HPFs). Statistically significant (P = 0.01) higher mean Ag NOR counts in ductal (2 ± 0.83) than in acinar cells (1.2 ± 0.01) of normal salivary tissue were found. Conclusion: It was concluded from the data of the present study that ductal cells of normal salivary tissue are a proliferative pool and an oncogenic target which plays an important role in the histogenesis of salivary gland tumors. Keywords: Histogenesis, HER-2/neu expression, AgNORs, Salivary gland neoplasms |
| format | Article |
| id | doaj-art-8f5bd7a7d20e4e28af877e2d42c7e866 |
| institution | DOAJ |
| issn | 1013-9052 |
| language | English |
| publishDate | 2010-04-01 |
| publisher | Springer |
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| series | Saudi Dental Journal |
| spelling | doaj-art-8f5bd7a7d20e4e28af877e2d42c7e8662025-08-20T03:20:31ZengSpringerSaudi Dental Journal1013-90522010-04-01222899410.1016/j.sdentj.2010.02.005A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissueEssam Taher M.A. Gaballah0Tel.: +966 0543307660.; Professor of Oral Pathology, Mansoura Faculty of Dentistry, Egypt; Associate Professor of Oral Pathology, College of Dentistry, King Khalid University, Saudi ArabiaSalivary gland neoplasms comprise phenotypically and biologically diverse lesions of uncertain histogenesis. Objectives: The present study was carried out to assess the immunohistochemical expression of HER-2/neu protein and of silver binding nucleolar organizer regions in normal salivary tissue. Materials and methods: Twenty paraffin blocks of salivary tumors containing surrounding normal salivary tissue were used in the study. One section was processed to investigate HER-2/neu protein expression and another section was stained to assess the mean Ag NOR counts in normal salivary tissue. Results: Only two cases of the studied normal salivary tissue showed HER-2/neu expression (10%), which was expressed only in ductal cells with 4.2 ± 2.1 mean number of reactive cells per five high power fields (HPFs). Statistically significant (P = 0.01) higher mean Ag NOR counts in ductal (2 ± 0.83) than in acinar cells (1.2 ± 0.01) of normal salivary tissue were found. Conclusion: It was concluded from the data of the present study that ductal cells of normal salivary tissue are a proliferative pool and an oncogenic target which plays an important role in the histogenesis of salivary gland tumors. Keywords: Histogenesis, HER-2/neu expression, AgNORs, Salivary gland neoplasmshttp://www.sciencedirect.com/science/article/pii/S1013905210000209 |
| spellingShingle | Essam Taher M.A. Gaballah A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue Saudi Dental Journal |
| title | A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue |
| title_full | A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue |
| title_fullStr | A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue |
| title_full_unstemmed | A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue |
| title_short | A study of HER-2/neu expression and silver binding nucleolar organizer regions (Ag NORs) in perilesional normal salivary gland tissue |
| title_sort | study of her 2 neu expression and silver binding nucleolar organizer regions ag nors in perilesional normal salivary gland tissue |
| url | http://www.sciencedirect.com/science/article/pii/S1013905210000209 |
| work_keys_str_mv | AT essamtahermagaballah astudyofher2neuexpressionandsilverbindingnucleolarorganizerregionsagnorsinperilesionalnormalsalivaryglandtissue AT essamtahermagaballah studyofher2neuexpressionandsilverbindingnucleolarorganizerregionsagnorsinperilesionalnormalsalivaryglandtissue |