“Lost in translation?” Animal research in the era of precision medicine
Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. However, given the intricate nature of human physiology and the complexities of diseases such as cancer, this p...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06084-3 |
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| author | Hamideh Frühwein Norbert W. Paul |
| author_facet | Hamideh Frühwein Norbert W. Paul |
| author_sort | Hamideh Frühwein |
| collection | DOAJ |
| description | Abstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. However, given the intricate nature of human physiology and the complexities of diseases such as cancer, this paper critically examines the role of animal experimentation in translational research, both from epistemological and ethical viewpoints. We argue that the ethical obligation to protect animals extends beyond their instrumental value for human benefit; it is rooted in the intrinsic value of their well-being. Consequently, we advocate for a paradigm shift in medical research: the adoption of new approach methodologies (NAMs) not merely as supplementary tools but as complete replacements for animal use in medical studies. In this context, replacement emerges as the key principle—an imperative that should be prioritized over all other considerations. |
| format | Article |
| id | doaj-art-8f4fc6a542d24c1da57a267315859a98 |
| institution | Kabale University |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-8f4fc6a542d24c1da57a267315859a982025-02-09T12:52:21ZengBMCJournal of Translational Medicine1479-58762025-02-0123111210.1186/s12967-025-06084-3“Lost in translation?” Animal research in the era of precision medicineHamideh Frühwein0Norbert W. Paul1Institute for History, Philosophy and Ethics of Medicine, University Medical CenterInstitute for History, Philosophy and Ethics of Medicine, University Medical CenterAbstract Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments before they proceed to human clinical trials. However, given the intricate nature of human physiology and the complexities of diseases such as cancer, this paper critically examines the role of animal experimentation in translational research, both from epistemological and ethical viewpoints. We argue that the ethical obligation to protect animals extends beyond their instrumental value for human benefit; it is rooted in the intrinsic value of their well-being. Consequently, we advocate for a paradigm shift in medical research: the adoption of new approach methodologies (NAMs) not merely as supplementary tools but as complete replacements for animal use in medical studies. In this context, replacement emerges as the key principle—an imperative that should be prioritized over all other considerations.https://doi.org/10.1186/s12967-025-06084-3Murine modelsEvidence-based medicinePrecision medicine3RAnimal ethics |
| spellingShingle | Hamideh Frühwein Norbert W. Paul “Lost in translation?” Animal research in the era of precision medicine Journal of Translational Medicine Murine models Evidence-based medicine Precision medicine 3R Animal ethics |
| title | “Lost in translation?” Animal research in the era of precision medicine |
| title_full | “Lost in translation?” Animal research in the era of precision medicine |
| title_fullStr | “Lost in translation?” Animal research in the era of precision medicine |
| title_full_unstemmed | “Lost in translation?” Animal research in the era of precision medicine |
| title_short | “Lost in translation?” Animal research in the era of precision medicine |
| title_sort | lost in translation animal research in the era of precision medicine |
| topic | Murine models Evidence-based medicine Precision medicine 3R Animal ethics |
| url | https://doi.org/10.1186/s12967-025-06084-3 |
| work_keys_str_mv | AT hamidehfruhwein lostintranslationanimalresearchintheeraofprecisionmedicine AT norbertwpaul lostintranslationanimalresearchintheeraofprecisionmedicine |