Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review
Objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions, which lead to epidermal detachment and may be life-threatening. Apart from supportive and systemic treatment of the disease, appropriate dressing and wound management are esse...
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Sociedade Portuguesa de Dermatologia e Venereologia
2025-04-01
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| Series: | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
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| Online Access: | https://www.portuguesejournalofdermatology.com/frame_eng.php?id=250 |
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| author | Maiara C. Macagnan Priscila de Cassia Francisco Breno S. Kliemann Adriano A. Mehl |
| author_facet | Maiara C. Macagnan Priscila de Cassia Francisco Breno S. Kliemann Adriano A. Mehl |
| author_sort | Maiara C. Macagnan |
| collection | DOAJ |
| description | Objectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions, which lead to epidermal detachment and may be life-threatening. Apart from supportive and systemic treatment of the disease, appropriate dressing and wound management are essential for the care of patients with SJS/TEN. This study aims to assess which are the most used dressings for SJS/TEN, and how wound management can contribute to skin healing. Methods: Searches were performed in Cochrane Library, Embase, MEDLINE, and PubMed databases, using the following search terms: (SJS OR TEN) AND (Wounds OR Dressings). Information extracted on dressings was used as well as local care (including materials for cleansing, debridement, topical therapy, fixation, and time for dressing changing) and time for re-epithelialization. Results: A total of 17 articles published in the last 11 years were selected. Six (35.3%) mentioned silver- based topical therapies as treatment of choice. Allografts and porcine xenografts were cited by a further 6 (35.3%) studies, biosynthetic dressings with a combination of collagen mesh and silicone by 4 (23.5%), petrolatum-based products by 4 (23.5%), and patient’s own detached skin as a biological dressing by 2 (11.8%) studies. Conclusion: Upon analysis of collected data, it was noted that little information is available on topical treatment in SJS and TEN, with no consensus on an ideal protocol for such cases. Therefore, dressing management for these disorders remains a challenge in care, and further research on this subject should be encouraged.
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| format | Article |
| id | doaj-art-8f4c3e62b8ff4dc1932b05f631486d91 |
| institution | DOAJ |
| issn | 2182-2395 2182-2409 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Sociedade Portuguesa de Dermatologia e Venereologia |
| record_format | Article |
| series | Revista da Sociedade Portuguesa de Dermatologia e Venereologia |
| spelling | doaj-art-8f4c3e62b8ff4dc1932b05f631486d912025-08-20T03:12:16ZengSociedade Portuguesa de Dermatologia e VenereologiaRevista da Sociedade Portuguesa de Dermatologia e Venereologia2182-23952182-24092025-04-01832Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic reviewMaiara C. Macagnan0Priscila de Cassia Francisco1Breno S. Kliemann2Adriano A. Mehl3Department of Dermatology, Hospital Santa Casa de Misericórdia de Curitiba, Paraná, BrazilDepartment of Dermatology, Hospital Santa Casa de Misericórdia de Curitiba, Paraná, BrazilDepartment of Dermatology, Hospital Santa Casa de Misericórdia de Curitiba, Paraná, BrazilDepartment of Dermatology, Hospital Santa Casa de Misericórdia de Curitiba, Paraná, BrazilObjectives: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions, which lead to epidermal detachment and may be life-threatening. Apart from supportive and systemic treatment of the disease, appropriate dressing and wound management are essential for the care of patients with SJS/TEN. This study aims to assess which are the most used dressings for SJS/TEN, and how wound management can contribute to skin healing. Methods: Searches were performed in Cochrane Library, Embase, MEDLINE, and PubMed databases, using the following search terms: (SJS OR TEN) AND (Wounds OR Dressings). Information extracted on dressings was used as well as local care (including materials for cleansing, debridement, topical therapy, fixation, and time for dressing changing) and time for re-epithelialization. Results: A total of 17 articles published in the last 11 years were selected. Six (35.3%) mentioned silver- based topical therapies as treatment of choice. Allografts and porcine xenografts were cited by a further 6 (35.3%) studies, biosynthetic dressings with a combination of collagen mesh and silicone by 4 (23.5%), petrolatum-based products by 4 (23.5%), and patient’s own detached skin as a biological dressing by 2 (11.8%) studies. Conclusion: Upon analysis of collected data, it was noted that little information is available on topical treatment in SJS and TEN, with no consensus on an ideal protocol for such cases. Therefore, dressing management for these disorders remains a challenge in care, and further research on this subject should be encouraged. https://www.portuguesejournalofdermatology.com/frame_eng.php?id=250Wounds. Stevens-Johnson syndrome. Toxic epidermal necrolysis. Dressings. |
| spellingShingle | Maiara C. Macagnan Priscila de Cassia Francisco Breno S. Kliemann Adriano A. Mehl Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review Revista da Sociedade Portuguesa de Dermatologia e Venereologia Wounds. Stevens-Johnson syndrome. Toxic epidermal necrolysis. Dressings. |
| title | Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review |
| title_full | Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review |
| title_fullStr | Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review |
| title_full_unstemmed | Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review |
| title_short | Wound management and dressing selection in Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review |
| title_sort | wound management and dressing selection in stevens johnson syndrome and toxic epidermal necrolysis a systematic review |
| topic | Wounds. Stevens-Johnson syndrome. Toxic epidermal necrolysis. Dressings. |
| url | https://www.portuguesejournalofdermatology.com/frame_eng.php?id=250 |
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