Detection of IL-27 in Patients with Visceral leishmaniasis
Visceral leishmaniasis (VL), caused by the protozoan parasites of the Leishmania donovani complex, remains one of the most significant neglected tropical diseases. Immune response mechanisms play a critical role in both resistance and pathogenesis of VL This study included 32 VL patients (19 fema...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
University of Thi-Qar
2025-06-01
|
| Series: | مجلة علوم ذي قار |
| Subjects: | |
| Online Access: | https://jsci.utq.edu.iq/index.php/main/article/view/1356 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849716155104624640 |
|---|---|
| author | Suha Abdullah Oudah ALfakar Khalil Ismail Abid Mohammed Ameen Abdul Hasan Al-Alwany Jinan Mousa |
| author_facet | Suha Abdullah Oudah ALfakar Khalil Ismail Abid Mohammed Ameen Abdul Hasan Al-Alwany Jinan Mousa |
| author_sort | Suha Abdullah Oudah ALfakar |
| collection | DOAJ |
| description |
Visceral leishmaniasis (VL), caused by the protozoan parasites of the Leishmania donovani complex, remains one of the most significant neglected tropical diseases. Immune response mechanisms play a critical role in both resistance and pathogenesis of VL This study included 32 VL patients (19 females, 13 males, 2 months to 5 years old) and 30 healthy controls (1 month to 11 years old). Blood samples were obtained from the Central Public Health Laboratories (CPHL). The serum was isolated by centrifuging blood samples at 1000g for 5 minutes. Human IL-27 levels were quantified using an ELISA kit (Elabscience Biotechnology Inc., USA; catalog No. E-EL-H2338) following the manufacturer's protocol. This study found significantly higher IL-27 levels in visceral leishmaniasis patients (54.120 pg/ml) compared to the control group (28.745 pg/ml). was a significant between the median levels of IL-27 in patients and the control group, where the p
IL-27 plays a significant role in the pathogenesis of visceral leishmaniasis. Its potential as a biomarker for active disease and for monitoring treatment response warrants further investigation, irrespective of the causative agent or geographic location.
|
| format | Article |
| id | doaj-art-8f4b5526e5cd49beb8aee6beda1557c8 |
| institution | DOAJ |
| issn | 1991-8690 2709-0256 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | University of Thi-Qar |
| record_format | Article |
| series | مجلة علوم ذي قار |
| spelling | doaj-art-8f4b5526e5cd49beb8aee6beda1557c82025-08-20T03:13:07ZengUniversity of Thi-Qarمجلة علوم ذي قار1991-86902709-02562025-06-0112110.32792/utq/utjsci/v12i1.1356Detection of IL-27 in Patients with Visceral leishmaniasisSuha Abdullah Oudah ALfakar0Khalil Ismail Abid Mohammed1Ameen Abdul Hasan Al-AlwanyJinan Mousa2Clinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad, Iraq.Department of Internal Medicine, College of Medicine, University of BaghdadClinical Communicable Diseases Research Unit, College of Medicine, University of Baghdad Visceral leishmaniasis (VL), caused by the protozoan parasites of the Leishmania donovani complex, remains one of the most significant neglected tropical diseases. Immune response mechanisms play a critical role in both resistance and pathogenesis of VL This study included 32 VL patients (19 females, 13 males, 2 months to 5 years old) and 30 healthy controls (1 month to 11 years old). Blood samples were obtained from the Central Public Health Laboratories (CPHL). The serum was isolated by centrifuging blood samples at 1000g for 5 minutes. Human IL-27 levels were quantified using an ELISA kit (Elabscience Biotechnology Inc., USA; catalog No. E-EL-H2338) following the manufacturer's protocol. This study found significantly higher IL-27 levels in visceral leishmaniasis patients (54.120 pg/ml) compared to the control group (28.745 pg/ml). was a significant between the median levels of IL-27 in patients and the control group, where the p IL-27 plays a significant role in the pathogenesis of visceral leishmaniasis. Its potential as a biomarker for active disease and for monitoring treatment response warrants further investigation, irrespective of the causative agent or geographic location. https://jsci.utq.edu.iq/index.php/main/article/view/1356Visceral leishmaniasis, IL-27, ELISA, biomarker, Iraq,Kala azar disease. |
| spellingShingle | Suha Abdullah Oudah ALfakar Khalil Ismail Abid Mohammed Ameen Abdul Hasan Al-Alwany Jinan Mousa Detection of IL-27 in Patients with Visceral leishmaniasis مجلة علوم ذي قار Visceral leishmaniasis, IL-27, ELISA, biomarker, Iraq,Kala azar disease. |
| title | Detection of IL-27 in Patients with Visceral leishmaniasis |
| title_full | Detection of IL-27 in Patients with Visceral leishmaniasis |
| title_fullStr | Detection of IL-27 in Patients with Visceral leishmaniasis |
| title_full_unstemmed | Detection of IL-27 in Patients with Visceral leishmaniasis |
| title_short | Detection of IL-27 in Patients with Visceral leishmaniasis |
| title_sort | detection of il 27 in patients with visceral leishmaniasis |
| topic | Visceral leishmaniasis, IL-27, ELISA, biomarker, Iraq,Kala azar disease. |
| url | https://jsci.utq.edu.iq/index.php/main/article/view/1356 |
| work_keys_str_mv | AT suhaabdullahoudahalfakar detectionofil27inpatientswithvisceralleishmaniasis AT khalilismailabidmohammed detectionofil27inpatientswithvisceralleishmaniasis AT ameenabdulhasanalalwany detectionofil27inpatientswithvisceralleishmaniasis AT jinanmousa detectionofil27inpatientswithvisceralleishmaniasis |