Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases
Abstract Background Thymic carcinoma has been classified into 12 subtypes, thymic lymphoepithelioma-like carcinoma (LELC) is a type of them, and has a pathological organization similar to that of lymphoepithelioma, an undifferentiated type of nasopharyngeal carcinoma. According to a report from the...
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Japan Surgical Society
2019-10-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-019-0706-6 |
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| author | Sachi Kawagishi Naoko Ose Masato Minami Soichiro Funaki Takashi Kanou Kenji Kimura Seiji Taniguchi Eiichi Morii Yasushi Shintani |
| author_facet | Sachi Kawagishi Naoko Ose Masato Minami Soichiro Funaki Takashi Kanou Kenji Kimura Seiji Taniguchi Eiichi Morii Yasushi Shintani |
| author_sort | Sachi Kawagishi |
| collection | DOAJ |
| description | Abstract Background Thymic carcinoma has been classified into 12 subtypes, thymic lymphoepithelioma-like carcinoma (LELC) is a type of them, and has a pathological organization similar to that of lymphoepithelioma, an undifferentiated type of nasopharyngeal carcinoma. According to a report from the International Thymic Malignancy Interest Group (ITMIG), thymic LELC is a rare tumor and accounts for 6% of all thymic carcinoma cases. We report two cases of surgical resection for thymic LELC and perform a search of other reports of thymic LELC, and clinical manifestations and follow-up data thus obtained are summarized. Case presentation Two patients underwent surgical resection for thymic LELC. In both, tumors were detected in the anterior mediastinum and a total thymectomy was performed. Each was diagnosed with thymic LELC and classified in accordance with the Masaoka staging system as modified stage II. In recent examinations, one patient was doing well after undergoing total resection, whereas early recurrence of distant lymph node metastasis was noted in the other at 5 months after the total resection procedure and died thereafter from a different disease. Conclusion We report two cases of surgical resection for thymic LELC. A successful total resection may positively affect prognosis: thus, long-term follow-up examinations must be performed. |
| format | Article |
| id | doaj-art-8f4b4d47e6d342cb8b0ae12498179afd |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-8f4b4d47e6d342cb8b0ae12498179afd2025-08-20T03:57:08ZengJapan Surgical SocietySurgical Case Reports2198-77932019-10-01511610.1186/s40792-019-0706-6Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two casesSachi Kawagishi0Naoko Ose1Masato Minami2Soichiro Funaki3Takashi Kanou4Kenji Kimura5Seiji Taniguchi6Eiichi Morii7Yasushi Shintani8Department of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineDepartment of Pathology, Osaka University Graduate School of MedicineDepartment of Pathology, Osaka University Graduate School of MedicineDepartment of Pathology, Osaka University Graduate School of MedicineDepartment of General Thoracic Surgery, Osaka University Graduate School of MedicineAbstract Background Thymic carcinoma has been classified into 12 subtypes, thymic lymphoepithelioma-like carcinoma (LELC) is a type of them, and has a pathological organization similar to that of lymphoepithelioma, an undifferentiated type of nasopharyngeal carcinoma. According to a report from the International Thymic Malignancy Interest Group (ITMIG), thymic LELC is a rare tumor and accounts for 6% of all thymic carcinoma cases. We report two cases of surgical resection for thymic LELC and perform a search of other reports of thymic LELC, and clinical manifestations and follow-up data thus obtained are summarized. Case presentation Two patients underwent surgical resection for thymic LELC. In both, tumors were detected in the anterior mediastinum and a total thymectomy was performed. Each was diagnosed with thymic LELC and classified in accordance with the Masaoka staging system as modified stage II. In recent examinations, one patient was doing well after undergoing total resection, whereas early recurrence of distant lymph node metastasis was noted in the other at 5 months after the total resection procedure and died thereafter from a different disease. Conclusion We report two cases of surgical resection for thymic LELC. A successful total resection may positively affect prognosis: thus, long-term follow-up examinations must be performed.http://link.springer.com/article/10.1186/s40792-019-0706-6Thymic lymphoepithelioma-like carcinomaThymusTotal thymectomyMasaoka staging system |
| spellingShingle | Sachi Kawagishi Naoko Ose Masato Minami Soichiro Funaki Takashi Kanou Kenji Kimura Seiji Taniguchi Eiichi Morii Yasushi Shintani Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases Surgical Case Reports Thymic lymphoepithelioma-like carcinoma Thymus Total thymectomy Masaoka staging system |
| title | Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases |
| title_full | Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases |
| title_fullStr | Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases |
| title_full_unstemmed | Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases |
| title_short | Total thymectomy for thymic lymphoepithelioma-like carcinoma—report of two cases |
| title_sort | total thymectomy for thymic lymphoepithelioma like carcinoma report of two cases |
| topic | Thymic lymphoepithelioma-like carcinoma Thymus Total thymectomy Masaoka staging system |
| url | http://link.springer.com/article/10.1186/s40792-019-0706-6 |
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