A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression
ObjectiveThis study compares the safety and effectiveness of theta-burst stimulation (TBS) and repetitive transcranial magnetic stimulation (rTMS) for treating treatment-resistant depression (TRD).MethodsWe reviewed randomized controlled trials (RCTs) that evaluated rTMS and TBS in managing TRD. Sea...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1504727/full |
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| author | Xiao Tao Zheng Wen Jing Wang Kui Yuan Guo Hui Yun Xie Jian Fang Liao Ming Sheng |
| author_facet | Xiao Tao Zheng Wen Jing Wang Kui Yuan Guo Hui Yun Xie Jian Fang Liao Ming Sheng |
| author_sort | Xiao Tao |
| collection | DOAJ |
| description | ObjectiveThis study compares the safety and effectiveness of theta-burst stimulation (TBS) and repetitive transcranial magnetic stimulation (rTMS) for treating treatment-resistant depression (TRD).MethodsWe reviewed randomized controlled trials (RCTs) that evaluated rTMS and TBS in managing TRD. Searches were conducted in PubMed, Embase, the Cochrane Library, and Web of Science for studies published up to July 31, 2024. Data from these studies were analyzed using statistical software.ResultsFive RCTs involving 1,196 patients were included, with 553 receiving rTMS and 663 receiving TBS. The analysis found no significant differences between rTMS and TBS in reducing depression [SMD = -0.07, 95% CI (-0.19, 0.04)] or anxiety [SMD = -0.02, 95% CI (-0.15, 0.11)], nor in side effects like headaches [OR = 1.00, 95% CI (0.72, 1.40)], nausea [OR = 1.42, 95% CI (0.79, 2.54)], or fatigue [OR = 0.87, 95% CI (0.46, 1.64)].ConclusionsBoth rTMS and TBS are similarly effective in reducing depression and anxiety symptoms, with comparable side effect profiles. However, TBS is more time-efficient, with sessions lasting only 192 seconds, making it a cost-effective option for patients. These findings support TBS as a practical treatment choice for TRD. |
| format | Article |
| id | doaj-art-8f48e0a33e3644f7a2af1ce3b1c6d03e |
| institution | Kabale University |
| issn | 1664-0640 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj-art-8f48e0a33e3644f7a2af1ce3b1c6d03e2025-02-03T06:33:27ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402025-02-011510.3389/fpsyt.2024.15047271504727A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depressionXiao TaoZheng Wen JingWang Kui YuanGuo Hui YunXie Jian FangLiao Ming ShengObjectiveThis study compares the safety and effectiveness of theta-burst stimulation (TBS) and repetitive transcranial magnetic stimulation (rTMS) for treating treatment-resistant depression (TRD).MethodsWe reviewed randomized controlled trials (RCTs) that evaluated rTMS and TBS in managing TRD. Searches were conducted in PubMed, Embase, the Cochrane Library, and Web of Science for studies published up to July 31, 2024. Data from these studies were analyzed using statistical software.ResultsFive RCTs involving 1,196 patients were included, with 553 receiving rTMS and 663 receiving TBS. The analysis found no significant differences between rTMS and TBS in reducing depression [SMD = -0.07, 95% CI (-0.19, 0.04)] or anxiety [SMD = -0.02, 95% CI (-0.15, 0.11)], nor in side effects like headaches [OR = 1.00, 95% CI (0.72, 1.40)], nausea [OR = 1.42, 95% CI (0.79, 2.54)], or fatigue [OR = 0.87, 95% CI (0.46, 1.64)].ConclusionsBoth rTMS and TBS are similarly effective in reducing depression and anxiety symptoms, with comparable side effect profiles. However, TBS is more time-efficient, with sessions lasting only 192 seconds, making it a cost-effective option for patients. These findings support TBS as a practical treatment choice for TRD.https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1504727/fulltranscranial magnetic stimulationtheta burst stimulationtreatment-resistant depressionmeta-analysisdepression |
| spellingShingle | Xiao Tao Zheng Wen Jing Wang Kui Yuan Guo Hui Yun Xie Jian Fang Liao Ming Sheng A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression Frontiers in Psychiatry transcranial magnetic stimulation theta burst stimulation treatment-resistant depression meta-analysis depression |
| title | A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression |
| title_full | A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression |
| title_fullStr | A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression |
| title_full_unstemmed | A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression |
| title_short | A meta-analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment-resistant depression |
| title_sort | meta analysis comparing the effectiveness and safety of repetitive transcranial magnetic stimulation versus theta burst stimulation for treatment resistant depression |
| topic | transcranial magnetic stimulation theta burst stimulation treatment-resistant depression meta-analysis depression |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1504727/full |
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