Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.

Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus.

STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1). Understanding how pY701-STAT1 is regulated by intracellular signaling remains a major challenge. Here we find that pY...

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Main Authors: Ying Ren, Peng Zhao, Jin Liu, Yukang Yuan, Qiao Cheng, Yibo Zuo, Liping Qian, Chang Liu, Tingting Guo, Liting Zhang, Xiaofang Wang, Guanghui Qian, Lemin Li, Jun Ge, Jianfeng Dai, Sidong Xiong, Hui Zheng
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-07-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005764&type=printable
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