Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging

Exploring the radiochemistry of PARP inhibitors: a new era in therapy and imaging

Abstract Background Poly (ADP-ribose) polymerase (PARP) inhibitors have emerged as a promising class of therapeutics, particularly in the treatment of cancers with defective DNA repair mechanisms, such as those with breast cancer genes (BRCA) mutations. Their effectiveness in cancer therapy is now w...

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Bibliographic Details
Main Authors: Gianluca Destro, Rebecca Rizzo, Chiara Rua, Raha Rouhbakhsh Azimi, Silvia Morbelli
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
PARP
PARP1
PARP inhibitor
Radiolabelling
PARP imaging
PARP therapy
Online Access:https://doi.org/10.1186/s41181-025-00364-5
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