Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes

Identification of novel therapeutic targets for atrial fibrillation through Mendelian randomization analysis of druggable genes

Background: Innovative therapeutic approaches are essential for treating atrial fibrillation (AF), yet genetic support for AF-specific drug targets remains limited. Methods: This Mendelian randomization (MR) study employed cis-expression quantitative trait loci (cis-eQTLs) to assess the causal relat...

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Bibliographic Details
Main Authors: Yining Ding, Rumeng Chen, Zhiwei Zheng, Shuling Xu, Menghua Liu, Chunyan Hou, Sen Li
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Experimental Gerontology
Subjects:
Genetics
Atrial fibrillation
Drug target
Mendelian randomization
Causal relationship
Online Access:http://www.sciencedirect.com/science/article/pii/S0531556525001263
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