Agomelatine as adjunctive therapy with SSRIs or SNRIs for major depressive disorder: a multicentre, double-blind, randomized, placebo-controlled trial

Agomelatine as adjunctive therapy with SSRIs or SNRIs for major depressive disorder: a multicentre, double-blind, randomized, placebo-controlled trial

Abstract Background In general, traditional antidepressants often have limited efficacy in patients with major depressive disorder (MDD). Agomelatine, as an antidepressant with a different mechanism of action, might have adjunctive effects on traditional antidepressants. This study aimed to investig...

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Bibliographic Details
Main Authors: Yumeng Ju, Wenwen Ou, Haoran Chen, Limin Yang, Yan Long, Hui Liang, Zhenman Xi, Mei Huang, Wentao Chen, Guanyi Lv, Fangzhou Shao, Bangshan Liu, Jin Liu, Zexuan Li, Mei Liao, Weiye Liang, Zhijian Yao, Yan Zhang, Lingjiang Li
Format: Article
Language:English
Published: BMC 2025-03-01
Series:BMC Medicine
Subjects:
Agomelatine
Adjunctive therapy
Major depressive disorder
RCT
Online Access:https://doi.org/10.1186/s12916-025-03951-0
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