Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study
Abstract Background Neoplasms are a major cause of mortality globally, where early diagnosis is essential for improving outcomes. Current diagnostic methods are often invasive, expensive, and inaccessible in resource-limited settings. This study explores the potential of electrocardiogram (ECG) data...
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| Format: | Article |
| Language: | English |
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BMC
2025-07-01
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| Series: | Cardio-Oncology |
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| Online Access: | https://doi.org/10.1186/s40959-025-00370-1 |
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| author | Juan Miguel Lopez Alcaraz Wilhelm Haverkamp Nils Strodthoff |
| author_facet | Juan Miguel Lopez Alcaraz Wilhelm Haverkamp Nils Strodthoff |
| author_sort | Juan Miguel Lopez Alcaraz |
| collection | DOAJ |
| description | Abstract Background Neoplasms are a major cause of mortality globally, where early diagnosis is essential for improving outcomes. Current diagnostic methods are often invasive, expensive, and inaccessible in resource-limited settings. This study explores the potential of electrocardiogram (ECG) data, a widely available and non-invasive tool for diagnosing neoplasms through cardiovascular changes linked to neoplastic presence. Methods A diagnostic pipeline combining tree-based machine learning models with Shapley value analysis for explainability was developed. The model was trained and internally validated on a large dataset and externally validated on an independent cohort to ensure robustness and generalizability. Key ECG features contributing to predictions were identified and analyzed. Results The model achieved high diagnostic accuracy in both internal testing and external validation cohorts. Shapley value analysis highlighted significant ECG features, including novel predictors. The approach is cost-effective, scalable, and suitable for resource-limited settings, offering insights into cardiovascular changes associated with neoplasms and their therapies. Conclusions This study demonstrates the feasibility of using ECG signals and machine learning for non-invasive neoplasm diagnosis. By providing interpretable insights into cardio-neoplasm interactions, this method addresses gaps in diagnostics and supports integration into broader diagnostic and therapeutic frameworks. |
| format | Article |
| id | doaj-art-8f2ffad84e8d45f788a1c03d0a23b3fb |
| institution | Kabale University |
| issn | 2057-3804 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardio-Oncology |
| spelling | doaj-art-8f2ffad84e8d45f788a1c03d0a23b3fb2025-08-20T03:42:03ZengBMCCardio-Oncology2057-38042025-07-0111111910.1186/s40959-025-00370-1Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated studyJuan Miguel Lopez Alcaraz0Wilhelm Haverkamp1Nils Strodthoff2AI4Health Division, Carl von Ossietzky Universität OldenburgDepartment of Cardiology, Angiology and Intensive Care Medicine, Charité Campus Mitte, German Heart Center of the Charité-University MedicineAI4Health Division, Carl von Ossietzky Universität OldenburgAbstract Background Neoplasms are a major cause of mortality globally, where early diagnosis is essential for improving outcomes. Current diagnostic methods are often invasive, expensive, and inaccessible in resource-limited settings. This study explores the potential of electrocardiogram (ECG) data, a widely available and non-invasive tool for diagnosing neoplasms through cardiovascular changes linked to neoplastic presence. Methods A diagnostic pipeline combining tree-based machine learning models with Shapley value analysis for explainability was developed. The model was trained and internally validated on a large dataset and externally validated on an independent cohort to ensure robustness and generalizability. Key ECG features contributing to predictions were identified and analyzed. Results The model achieved high diagnostic accuracy in both internal testing and external validation cohorts. Shapley value analysis highlighted significant ECG features, including novel predictors. The approach is cost-effective, scalable, and suitable for resource-limited settings, offering insights into cardiovascular changes associated with neoplasms and their therapies. Conclusions This study demonstrates the feasibility of using ECG signals and machine learning for non-invasive neoplasm diagnosis. By providing interpretable insights into cardio-neoplasm interactions, this method addresses gaps in diagnostics and supports integration into broader diagnostic and therapeutic frameworks.https://doi.org/10.1186/s40959-025-00370-1Neoplasm diagnosisElectrocardiogram (ECG)Explainable Artificial Intelligence (XAI)Machine Learning |
| spellingShingle | Juan Miguel Lopez Alcaraz Wilhelm Haverkamp Nils Strodthoff Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study Cardio-Oncology Neoplasm diagnosis Electrocardiogram (ECG) Explainable Artificial Intelligence (XAI) Machine Learning |
| title | Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study |
| title_full | Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study |
| title_fullStr | Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study |
| title_full_unstemmed | Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study |
| title_short | Explainable machine learning for neoplasms diagnosis via electrocardiograms: an externally validated study |
| title_sort | explainable machine learning for neoplasms diagnosis via electrocardiograms an externally validated study |
| topic | Neoplasm diagnosis Electrocardiogram (ECG) Explainable Artificial Intelligence (XAI) Machine Learning |
| url | https://doi.org/10.1186/s40959-025-00370-1 |
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