Safety and efficacy of 3- and 5-day regimens of levamisole in loiasis: a randomized, placebo-controlled, double-blind clinical trial

Safety and efficacy of 3- and 5-day regimens of levamisole in loiasis: a randomized, placebo-controlled, double-blind clinical trial

Abstract Individuals with high Loa loa microfilarial densities (MFD) risk serious adverse events (SAEs) following ivermectin treatment. A single dose of levamisole (LEV) induces a temporary, progressive MFD decrease. This double-blind, randomized, placebo-controlled trial evaluated the safety and ef...

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Main Authors: Cédric B. Chesnais, Marlhand C. Hemilembolo, Bachiratou A. Sahm, Florentin Toutin, Ericson Djeutassong, Nadia Nga-Elomo, Benjamin Cuer, Mas A. Ntsiba-N’Goulou, Miveck Pakat, Sébastien D. S. Pion, François Missamou, Michel Boussinesq, Jérémy T. Campillo
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61479-6
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