Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry
Background. Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated the associations of visceral fat area (VFA), serum ad...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/1762161 |
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| author | Masafumi Kurajoh Shinya Fukumoto Takayo Murase Takashi Nakamura Takuma Ishihara Hirofumi Go Kouji Yamamoto Shinya Nakatani Akihiro Tsuda Tomoaki Morioka Katsuhito Mori Yasuo Imanishi Masaaki Inaba Masanori Emoto |
| author_facet | Masafumi Kurajoh Shinya Fukumoto Takayo Murase Takashi Nakamura Takuma Ishihara Hirofumi Go Kouji Yamamoto Shinya Nakatani Akihiro Tsuda Tomoaki Morioka Katsuhito Mori Yasuo Imanishi Masaaki Inaba Masanori Emoto |
| author_sort | Masafumi Kurajoh |
| collection | DOAJ |
| description | Background. Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated the associations of visceral fat area (VFA), serum adiponectin level, and insulin resistance with plasma XOR activity using our novel highly sensitive assay based on [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Methods. This cross-sectional study included 193 subjects (92 males and 101 females) registered in the MedCity21 health examination registry. Plasma XOR activity, serum adiponectin level, and VFA obtained by computed tomography were measured, and insulin resistance was determined based on the homeostasis model assessment (HOMA-IR) index. Results. The mean values for VFA, log HOMA-IR, and log plasma XOR activity were 76.8 ± 45.8 cm2, 0.14 ± 0.30, and 1.50 ± 0.44 pmol/h/mL, respectively. Multiple regression analysis showed that HOMA-IR was significantly (p=0.020) associated with plasma XOR activity independent of other factors, including VFA and adiponectin level, as well as age, sex, alcohol drinking habit, smoking habit, alanine transaminase, HbA1c, and eGFR. The “sex∗HOMA−IR” interaction was not significant (p=0.89), indicating that sex difference does not have an effect on the relationship between HOMA-IR and plasma XOR activity. Conclusions. Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity. |
| format | Article |
| id | doaj-art-8f2766041ba54d7c877a28a96a49026e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8f2766041ba54d7c877a28a96a49026e2025-02-03T05:50:46ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/17621611762161Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination RegistryMasafumi Kurajoh0Shinya Fukumoto1Takayo Murase2Takashi Nakamura3Takuma Ishihara4Hirofumi Go5Kouji Yamamoto6Shinya Nakatani7Akihiro Tsuda8Tomoaki Morioka9Katsuhito Mori10Yasuo Imanishi11Masaaki Inaba12Masanori Emoto13Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Premier Preventive Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanMie Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Inabe, Mie, JapanMie Research Laboratories, Sanwa Kagaku Kenkyusho Co., Ltd., Inabe, Mie, JapanInnovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu, JapanDepartment of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Nephrology, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanDepartment of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Osaka, JapanBackground. Higher levels of uric acid production have been reported in individuals with visceral fat obesity, and obesity is known to enhance xanthine oxidoreductase (XOR) activity, although the precise mechanism remains unclear. We investigated the associations of visceral fat area (VFA), serum adiponectin level, and insulin resistance with plasma XOR activity using our novel highly sensitive assay based on [13C2,15N2] xanthine and liquid chromatography/triple quadrupole mass spectrometry. Methods. This cross-sectional study included 193 subjects (92 males and 101 females) registered in the MedCity21 health examination registry. Plasma XOR activity, serum adiponectin level, and VFA obtained by computed tomography were measured, and insulin resistance was determined based on the homeostasis model assessment (HOMA-IR) index. Results. The mean values for VFA, log HOMA-IR, and log plasma XOR activity were 76.8 ± 45.8 cm2, 0.14 ± 0.30, and 1.50 ± 0.44 pmol/h/mL, respectively. Multiple regression analysis showed that HOMA-IR was significantly (p=0.020) associated with plasma XOR activity independent of other factors, including VFA and adiponectin level, as well as age, sex, alcohol drinking habit, smoking habit, alanine transaminase, HbA1c, and eGFR. The “sex∗HOMA−IR” interaction was not significant (p=0.89), indicating that sex difference does not have an effect on the relationship between HOMA-IR and plasma XOR activity. Conclusions. Our results indicate that insulin resistance is associated with plasma XOR activity and that relationship is independent of visceral adiposity and adiponectin level, suggesting that the development of insulin resistance resulting from increased visceral adiposity and/or reduced serum adiponectin contributes to increased uric acid production by stimulating XOR activity.http://dx.doi.org/10.1155/2019/1762161 |
| spellingShingle | Masafumi Kurajoh Shinya Fukumoto Takayo Murase Takashi Nakamura Takuma Ishihara Hirofumi Go Kouji Yamamoto Shinya Nakatani Akihiro Tsuda Tomoaki Morioka Katsuhito Mori Yasuo Imanishi Masaaki Inaba Masanori Emoto Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry International Journal of Endocrinology |
| title | Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry |
| title_full | Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry |
| title_fullStr | Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry |
| title_full_unstemmed | Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry |
| title_short | Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry |
| title_sort | insulin resistance associated with plasma xanthine oxidoreductase activity independent of visceral adiposity and adiponectin level medcity21 health examination registry |
| url | http://dx.doi.org/10.1155/2019/1762161 |
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