CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis

CROT overactivation within peroxisomes confers chemoresistance to non-small cell lung cancer by targeting fatty acid oxidation-Nrf2-ferroptosis resistance axis

A key factor that limits the therapeutic benefits for non-small cell lung cancer (NSCLC) patients is chemoresistance. Even so, a detailed understanding of the process involved in chemoresistance acquisition and development at molecular level in NSCLC is still lacking. Here, we established chemo-resi...

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Bibliographic Details
Main Authors: Chunyu Hua, Guohui Zhang, Wendan Yu, Jie Zhou, Liyuan Ru, Guoqing Xue, Lina Zheng, Meiyi Wang, Yiwei Wang, Dianlin Yu, Qijing Wang, Jiaxin Liu, Ruonan Wang, Wuguo Deng, Ranran Tang, Wei Guo
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Pharmacological Research
Subjects:
NSCLC
Chemoresistance
CROT
Peroxisomes
Nrf2
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S1043661825003366
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