Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice

Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice

Abstract Background Tri-ortho-cresyl phosphate (TOCP), a widely used plasticizer, has been shown to impair ovarian function. While tanshinone IIA exhibits ovarian protective effects in aging models, its potential to counteract TOCP-induced ovarian damage and associated signaling mechanisms remains u...

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Bibliographic Details
Main Authors: Zhangqiang Ma, Na Hu, Liping Zheng, Yue Xue, Chong Zhou, Wencan Wang, Xiu Cheng, Tao Luo, Jianlin Yu, Liaoliao Hu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Ovarian Research
Subjects:
Hippo signaling pathway
Apoptosis
Tanshinone IIA
Tri-ortho-cresyl phosphate
Granulosa cells
Online Access:https://doi.org/10.1186/s13048-025-01671-w
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