Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study
Abstract. Background. The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 in India has been declared a public health emergency. Many patients with COVID-19 experience cardiac injury. Patients with COVID-19 admitted to the intensive care unit...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2022-09-01
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| Series: | Emergency and Critical Care Medicine |
| Online Access: | http://journals.lww.com/10.1097/EC9.0000000000000057 |
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| author | Neeraj Kumar Sarfaraz Ahmad Mala Mahto Abhyuday Kumar Prabhat K. Singh |
| author_facet | Neeraj Kumar Sarfaraz Ahmad Mala Mahto Abhyuday Kumar Prabhat K. Singh |
| author_sort | Neeraj Kumar |
| collection | DOAJ |
| description | Abstract. Background. The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 in India has been declared a public health emergency. Many patients with COVID-19 experience cardiac injury. Patients with COVID-19 admitted to the intensive care unit (ICU) with acute myocardial injury showed increased high-sensitivity troponin levels. Abnormal troponin levels may indicate myocardial injury and are commonly associated with COVID-19.
Methods. We conducted a retrospective observational study of 44 patients with severe COVID-19 in ICU during the second wave. The primary end point of our retrospective study was 28-day mortality, and the time of ICU admission was designated as day 0. We extracted and analyzed cardiac biomarkers, such as creatine kinase (CK), creatine kinase-MB (CK-MB), B-type natriuretic peptide (BNP), and high-sensitivity cardiac troponin I (hs-cTnI), and various inflammatory markers such as C-reactive protein (CRP) level, interleukin 6 (IL-6), d-dimer, ferritin, lactate dehydrogenase, IL-6, and procalcitonin in patients with severe COVID-19 at ICU admission and 72 hours after ICU admission from our electronic medical record system.
Results. The best cutoff of BNP were 326.8 and 398.5 pg/mL, CK were 195.95 and 180.12 U/L, CK-MB were 112.10 and 108.5 U/L, and hs-cTnI were 0.035 and 0.025 ng/mL, at ICU admission and 72 hours after ICU admission for predicting 28-day mortality among nonsurvivors.
Conclusion. In patients with severe COVID-19, CK and hs-cTnI may be considered effective and valuable predictive cardiac biomarkers among nonsurvivors and predict poor prognosis. |
| format | Article |
| id | doaj-art-8f237cd2cc6c4ccbbcf7aec8cce8bc17 |
| institution | DOAJ |
| issn | 2097-0617 2693-860X |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Emergency and Critical Care Medicine |
| spelling | doaj-art-8f237cd2cc6c4ccbbcf7aec8cce8bc172025-08-20T03:17:55ZengWolters Kluwer Health/LWWEmergency and Critical Care Medicine2097-06172693-860X2022-09-012312212710.1097/EC9.0000000000000057202209000-00005Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective studyNeeraj Kumar0Sarfaraz Ahmad1Mala Mahto2Abhyuday Kumar3Prabhat K. Singh4a Department of Trauma and Emergency, All India Institute of Medical Sciences Patna, Bihar, Indiab Department of Anaesthesiology, All India Institute of Medical Sciences Patna, Bihar, Indiac Department of Biochemistry, All India Institute of Medical Sciences Patna, Bihar, Indiab Department of Anaesthesiology, All India Institute of Medical Sciences Patna, Bihar, Indiad Director, All India Institute of Medical Sciences Patna, Bihar, India.Abstract. Background. The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 in India has been declared a public health emergency. Many patients with COVID-19 experience cardiac injury. Patients with COVID-19 admitted to the intensive care unit (ICU) with acute myocardial injury showed increased high-sensitivity troponin levels. Abnormal troponin levels may indicate myocardial injury and are commonly associated with COVID-19. Methods. We conducted a retrospective observational study of 44 patients with severe COVID-19 in ICU during the second wave. The primary end point of our retrospective study was 28-day mortality, and the time of ICU admission was designated as day 0. We extracted and analyzed cardiac biomarkers, such as creatine kinase (CK), creatine kinase-MB (CK-MB), B-type natriuretic peptide (BNP), and high-sensitivity cardiac troponin I (hs-cTnI), and various inflammatory markers such as C-reactive protein (CRP) level, interleukin 6 (IL-6), d-dimer, ferritin, lactate dehydrogenase, IL-6, and procalcitonin in patients with severe COVID-19 at ICU admission and 72 hours after ICU admission from our electronic medical record system. Results. The best cutoff of BNP were 326.8 and 398.5 pg/mL, CK were 195.95 and 180.12 U/L, CK-MB were 112.10 and 108.5 U/L, and hs-cTnI were 0.035 and 0.025 ng/mL, at ICU admission and 72 hours after ICU admission for predicting 28-day mortality among nonsurvivors. Conclusion. In patients with severe COVID-19, CK and hs-cTnI may be considered effective and valuable predictive cardiac biomarkers among nonsurvivors and predict poor prognosis.http://journals.lww.com/10.1097/EC9.0000000000000057 |
| spellingShingle | Neeraj Kumar Sarfaraz Ahmad Mala Mahto Abhyuday Kumar Prabhat K. Singh Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study Emergency and Critical Care Medicine |
| title | Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study |
| title_full | Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study |
| title_fullStr | Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study |
| title_full_unstemmed | Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study |
| title_short | Prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe COVID-19: a single-center, retrospective study |
| title_sort | prognostic value of elevated cardiac and inflammatory biomarkers in patients with severe covid 19 a single center retrospective study |
| url | http://journals.lww.com/10.1097/EC9.0000000000000057 |
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