Novel Micellar Formulation of Silymarin (Milk Thistle) with Enhanced Bioavailability in a Double-Blind, Randomized, Crossover Human Trial

Novel Micellar Formulation of Silymarin (Milk Thistle) with Enhanced Bioavailability in a Double-Blind, Randomized, Crossover Human Trial

<b>Background:</b> Silymarin, a flavonoid complex, and the main bioactive component of milk thistle (<i>Silybum marianum</i>), is known for its hepatoprotective properties but suffers from poor bioavailability due to its low solubility and extensive first-pass metabolism. <...

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Bibliographic Details
Main Authors: Chuck Chang, Yiming Zhang, Yun Chai Kuo, Min Du, Kyle Roh, Roland Gahler, Afoke Ibi, Julia Solnier
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceutics
Subjects:
milk thistle
silymarin
micelles
LipoMicel
bioavailability
pharmacokinetics
Online Access:https://www.mdpi.com/1999-4923/17/7/880
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