Mutations of MRGPRX2, drug sensitivity, and genetic markers related to disease

Mutations of MRGPRX2, drug sensitivity, and genetic markers related to disease

Mast cells (MCs) express the novel class A Mas-related G protein–coupled receptor X2 (MRGPRX2). Additionally, neurons and other leukocytes including basophils express MRGPRX2. MC activation dependent on IgE is a well-established and extensively researched mechanism of type I hypersensitivity and all...

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Bibliographic Details
Main Authors: Subashini Hemamala Ratnayake, MSc, BSc, Kanishka Senarath, PhD, Dakshika Gangani, PhD, Dhanushka Dasanayake, MBBS, Rajiva de Silva, MBBS, Shiroma Handunnetti, PhD
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Journal of Allergy and Clinical Immunology: Global
Subjects:
MRGPRX2
mutations
allergy
mast cells
SNPs
agonists
Online Access:http://www.sciencedirect.com/science/article/pii/S2772829325000682
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