Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors
Abstract Colon epithelial tumor (CEТ) malignancy grade determination cannot fully rely on the tumor cells’ nuclei DNA content and mitotic index as independent factors. The opposite vectors of the cellular spectrum can distinguish CEТ. The first one is characterized by the decrease in mitotic acti...
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| Format: | Article |
| Language: | English |
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Zaporizhzhia State Medical and Pharmaceutical University
2013-08-01
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| Series: | Patologìâ |
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| Online Access: | http://pat.zsmu.edu.ua/article/view/17361/15051 |
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| author | A.N. Grabovoy S.A. Antoniuk E.A. Vorobey |
| author_facet | A.N. Grabovoy S.A. Antoniuk E.A. Vorobey |
| author_sort | A.N. Grabovoy |
| collection | DOAJ |
| description | Abstract
Colon epithelial tumor (CEТ) malignancy grade determination cannot fully rely on the tumor cells’ nuclei DNA content and mitotic index as independent factors. The opposite vectors of the cellular spectrum can distinguish CEТ. The first one is characterized by the decrease in mitotic activity, and the second, contrariwise, by its increase, with increased cells’ DNA content. CEТ can be divided into those in which there is an increase in the average cells’ nuclei DNA content due to high proliferative activity (a large proportion of cells in which DNA synthesis occurs), and those in which this component is increased due to an increase of the cells proportion in the polyploid cells’ spectrum. |
| format | Article |
| id | doaj-art-8f14ee52f59e4a6e9e9cd5838ed2e6cc |
| institution | Kabale University |
| issn | 2306-8027 2310-1237 |
| language | English |
| publishDate | 2013-08-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Patologìâ |
| spelling | doaj-art-8f14ee52f59e4a6e9e9cd5838ed2e6cc2025-08-20T03:36:58ZengZaporizhzhia State Medical and Pharmaceutical UniversityPatologìâ2306-80272310-12372013-08-012131610.14739/2310-1237.2013.2.17361Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumorsA.N. GrabovoyS.A. AntoniukE.A. VorobeyAbstract Colon epithelial tumor (CEТ) malignancy grade determination cannot fully rely on the tumor cells’ nuclei DNA content and mitotic index as independent factors. The opposite vectors of the cellular spectrum can distinguish CEТ. The first one is characterized by the decrease in mitotic activity, and the second, contrariwise, by its increase, with increased cells’ DNA content. CEТ can be divided into those in which there is an increase in the average cells’ nuclei DNA content due to high proliferative activity (a large proportion of cells in which DNA synthesis occurs), and those in which this component is increased due to an increase of the cells proportion in the polyploid cells’ spectrum.http://pat.zsmu.edu.ua/article/view/17361/15051colon epithelial tumorKi-67nucleic acids |
| spellingShingle | A.N. Grabovoy S.A. Antoniuk E.A. Vorobey Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors Patologìâ colon epithelial tumor Ki-67 nucleic acids |
| title | Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors |
| title_full | Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors |
| title_fullStr | Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors |
| title_full_unstemmed | Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors |
| title_short | Mitotic activity and nucleic acids content in the cells’ nuclei of epithelial colon tumors |
| title_sort | mitotic activity and nucleic acids content in the cells nuclei of epithelial colon tumors |
| topic | colon epithelial tumor Ki-67 nucleic acids |
| url | http://pat.zsmu.edu.ua/article/view/17361/15051 |
| work_keys_str_mv | AT angrabovoy mitoticactivityandnucleicacidscontentinthecellsnucleiofepithelialcolontumors AT saantoniuk mitoticactivityandnucleicacidscontentinthecellsnucleiofepithelialcolontumors AT eavorobey mitoticactivityandnucleicacidscontentinthecellsnucleiofepithelialcolontumors |