Pheochromocytomas/Paragangliomas and two cases
Pheochromocytomas are catecholamine-producing neuroendocrine tumours that arise from the adrenal medulla or extramedullary pheochromoblasts with highly variable clinical presentation, including episodes of headache, sweating, palpitations and hypertension. Due to the non-specificity of the symptoms...
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| Format: | Article |
| Language: | English |
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AOSIS
2007-06-01
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| Series: | South African Family Practice |
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| Online Access: | https://safpj.co.za/index.php/safpj/article/view/849 |
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| author | W. van Vuuren N.E. Nyakale F.S.J. Naude B.J. Meyer M.M. Sathekge |
| author_facet | W. van Vuuren N.E. Nyakale F.S.J. Naude B.J. Meyer M.M. Sathekge |
| author_sort | W. van Vuuren |
| collection | DOAJ |
| description | Pheochromocytomas are catecholamine-producing neuroendocrine tumours that arise from the adrenal medulla or extramedullary pheochromoblasts with highly variable clinical presentation, including episodes of headache, sweating, palpitations and hypertension. Due to the non-specificity of the symptoms there is usually a delay between the onset of symptoms and the final diagnosis. To make a firm diagnosis, biochemical testing of the blood (catecholamines) or urine (metanephrines and VMA) are mandatory. Many stimuli increase circulating catecholamines and metabolites and must receive due attention to prevent false-positive results. Therapeutically, surgery is the gold standard. To minimise complications during and post surgery the lesion(s) should be carefully localised via imaging studies. Adequate pre- and postoperative medical treatment is important. The history, diagnosis and therapy of two patients—the one with a paraganglioma of the organ of Zuckerkandl, the other with a intra thoracic paraganglioma are presented. |
| format | Article |
| id | doaj-art-8f0a37ccd0a9419ebbed1fad564c37d0 |
| institution | DOAJ |
| issn | 2078-6190 2078-6204 |
| language | English |
| publishDate | 2007-06-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Family Practice |
| spelling | doaj-art-8f0a37ccd0a9419ebbed1fad564c37d02025-08-20T03:07:21ZengAOSISSouth African Family Practice2078-61902078-62042007-06-0149510.1080/20786204.2007.10873557728Pheochromocytomas/Paragangliomas and two casesW. van Vuuren0N.E. Nyakale1F.S.J. Naude2B.J. Meyer3M.M. Sathekge4University of PretoriaUniversity of PretoriaUniversity of PretoriaUniversity of PretoriaUniversity of PretoriaPheochromocytomas are catecholamine-producing neuroendocrine tumours that arise from the adrenal medulla or extramedullary pheochromoblasts with highly variable clinical presentation, including episodes of headache, sweating, palpitations and hypertension. Due to the non-specificity of the symptoms there is usually a delay between the onset of symptoms and the final diagnosis. To make a firm diagnosis, biochemical testing of the blood (catecholamines) or urine (metanephrines and VMA) are mandatory. Many stimuli increase circulating catecholamines and metabolites and must receive due attention to prevent false-positive results. Therapeutically, surgery is the gold standard. To minimise complications during and post surgery the lesion(s) should be carefully localised via imaging studies. Adequate pre- and postoperative medical treatment is important. The history, diagnosis and therapy of two patients—the one with a paraganglioma of the organ of Zuckerkandl, the other with a intra thoracic paraganglioma are presented.https://safpj.co.za/index.php/safpj/article/view/849pheochromocytomasparagangliomas |
| spellingShingle | W. van Vuuren N.E. Nyakale F.S.J. Naude B.J. Meyer M.M. Sathekge Pheochromocytomas/Paragangliomas and two cases South African Family Practice pheochromocytomas paragangliomas |
| title | Pheochromocytomas/Paragangliomas and two cases |
| title_full | Pheochromocytomas/Paragangliomas and two cases |
| title_fullStr | Pheochromocytomas/Paragangliomas and two cases |
| title_full_unstemmed | Pheochromocytomas/Paragangliomas and two cases |
| title_short | Pheochromocytomas/Paragangliomas and two cases |
| title_sort | pheochromocytomas paragangliomas and two cases |
| topic | pheochromocytomas paragangliomas |
| url | https://safpj.co.za/index.php/safpj/article/view/849 |
| work_keys_str_mv | AT wvanvuuren pheochromocytomasparagangliomasandtwocases AT nenyakale pheochromocytomasparagangliomasandtwocases AT fsjnaude pheochromocytomasparagangliomasandtwocases AT bjmeyer pheochromocytomasparagangliomasandtwocases AT mmsathekge pheochromocytomasparagangliomasandtwocases |