DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells

DGCR2 targeting affibody molecules for delivery of drugs and imaging reagents to human beta cells

Abstract A distinctive feature of both type 1 and type 2 diabetes is the waning of insulin-secreting beta cells in the pancreas. New methods for direct and specific targeting of the beta cells could provide platforms for delivery of pharmaceutical reagents. Imaging techniques such as Positron Emissi...

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Bibliographic Details
Main Authors: Pierre Cheung, Jonas Persson, Bo Zhang, Svitlana Vasylovska, Joey Lau, Sofie Invast, Olle Korsgren, Stefan Ståhl, John Löfblom, Olof Eriksson
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Affibody molecule
Beta cells
DGCR2
Drug delivery
Imaging reagents
Online Access:https://doi.org/10.1038/s41598-024-84574-y
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