Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury
The liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. So far, the histological features have not been compared with DDW-...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2015/913793 |
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| author | Akemi Tsutsui Yasuni Nakanuma Kouichi Takaguchi Satoko Nakamura Hiroshi Shibata Nobuyuki Baba Tomonori Senoh Takuya Nagano Hiroko Ikeda |
| author_facet | Akemi Tsutsui Yasuni Nakanuma Kouichi Takaguchi Satoko Nakamura Hiroshi Shibata Nobuyuki Baba Tomonori Senoh Takuya Nagano Hiroko Ikeda |
| author_sort | Akemi Tsutsui |
| collection | DOAJ |
| description | The liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. So far, the histological features have not been compared with DDW-J scale in detail. Herein, we examined the correlation between liver biopsy findings and clinical features, particularly DDW-J scales. A total of 80 patients with liver injuries of unknown cause were enrolled. Based on the histological findings, these cases were categorized into 3 groups: A (DILI was strongly suspected), B (DILI was suspected), and C (DILI should be considered in the differential diagnosis). Histological groups and DDW-J scale were moderately correlated (κ=0.60). The mean total DDW-J scale scores were as follows: 4.89 for A, 3.26 for B, and 0.75 for C (p<0.05). While hepatocellular type was coincided in a majority of cases by histological and DDW-J scale evaluation, cholestatic type was not well coincided. In conclusion, biopsy findings and DDW-J scale were well correlated, and the hepatocellular type of liver injuries was well coincided by both evaluations, though there were several discrepant cases, particularly in cholestatic type. |
| format | Article |
| id | doaj-art-8f07b891416e4786968afb9bd487d59b |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-8f07b891416e4786968afb9bd487d59b2025-02-03T05:46:25ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/913793913793Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver InjuryAkemi Tsutsui0Yasuni Nakanuma1Kouichi Takaguchi2Satoko Nakamura3Hiroshi Shibata4Nobuyuki Baba5Tomonori Senoh6Takuya Nagano7Hiroko Ikeda8Department of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, JapanDepartment of Pathology, Shizuoka Cancer Center, Shizuoka 411-0934, JapanDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, JapanSection of Diagnostic Pathology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, JapanDepartment of Gastroenterology, Tokushima Prefectural Central Hospital, Tokushima 770-0042, JapanDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, JapanDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, JapanDepartment of Hepatology, Kagawa Prefectural Central Hospital, Kagawa 760-8557, JapanSection of Diagnostic Pathology, Kanazawa University Hospital, Kanazawa 920-0934, JapanThe liver biopsy remains a valuable tool in the diagnosis of drug-induced liver injury (DILI). The Digestive Disease Week Japan 2004 (DDW-J) scale proposed as an objective tool for the diagnosis of DILI has been widely used in Japan. So far, the histological features have not been compared with DDW-J scale in detail. Herein, we examined the correlation between liver biopsy findings and clinical features, particularly DDW-J scales. A total of 80 patients with liver injuries of unknown cause were enrolled. Based on the histological findings, these cases were categorized into 3 groups: A (DILI was strongly suspected), B (DILI was suspected), and C (DILI should be considered in the differential diagnosis). Histological groups and DDW-J scale were moderately correlated (κ=0.60). The mean total DDW-J scale scores were as follows: 4.89 for A, 3.26 for B, and 0.75 for C (p<0.05). While hepatocellular type was coincided in a majority of cases by histological and DDW-J scale evaluation, cholestatic type was not well coincided. In conclusion, biopsy findings and DDW-J scale were well correlated, and the hepatocellular type of liver injuries was well coincided by both evaluations, though there were several discrepant cases, particularly in cholestatic type.http://dx.doi.org/10.1155/2015/913793 |
| spellingShingle | Akemi Tsutsui Yasuni Nakanuma Kouichi Takaguchi Satoko Nakamura Hiroshi Shibata Nobuyuki Baba Tomonori Senoh Takuya Nagano Hiroko Ikeda Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury Mediators of Inflammation |
| title | Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury |
| title_full | Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury |
| title_fullStr | Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury |
| title_full_unstemmed | Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury |
| title_short | Comparison of Liver Biopsy Findings with the Digestive Disease Week Japan 2004 Scale for Diagnosis of Drug-Induced Liver Injury |
| title_sort | comparison of liver biopsy findings with the digestive disease week japan 2004 scale for diagnosis of drug induced liver injury |
| url | http://dx.doi.org/10.1155/2015/913793 |
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