Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review
We report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/μL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2009/348507 |
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| author | Peninnah Oberdorfer Charles H. Washington Kamornwan Katanyuwong Podjanee Jittamala |
| author_facet | Peninnah Oberdorfer Charles H. Washington Kamornwan Katanyuwong Podjanee Jittamala |
| author_sort | Peninnah Oberdorfer |
| collection | DOAJ |
| description | We report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/μL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the initiation of highly active antiretroviral therapy (HAART), the MRI showed progressive white matter lesions with asymmetrical deep and subcortical white matter lesions over the left frontotemporoparietal region and the right frontal lobe. Immune Reconstitution Inflammatory Syndrome (IRIS) was suspected, and the patient was treated with methylprednisolone. His clinical symptoms worsened and despite therapy the patient deteriorated. |
| format | Article |
| id | doaj-art-8efb2cbcdc7849c9889f2d1a8d92299e |
| institution | Kabale University |
| issn | 1687-9740 1687-9759 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Pediatrics |
| spelling | doaj-art-8efb2cbcdc7849c9889f2d1a8d92299e2025-08-20T03:37:16ZengWileyInternational Journal of Pediatrics1687-97401687-97592009-01-01200910.1155/2009/348507348507Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature ReviewPeninnah Oberdorfer0Charles H. Washington1Kamornwan Katanyuwong2Podjanee Jittamala3Division of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDepartment of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USADivision of Neurology, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandDivision of Infectious Diseases, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, ThailandWe report a case of a perinatally HIV-infected patient aged 9 years, who presented with right-sided hemiplegia. His initial CD4 T-cell was of 0.21% (4 cells/μL) and plasma HIV RNA virus of 185 976 copies/mL (log 5.27). Plasma and CSF samples were subsequently positive for JCV. Twelve days after the initiation of highly active antiretroviral therapy (HAART), the MRI showed progressive white matter lesions with asymmetrical deep and subcortical white matter lesions over the left frontotemporoparietal region and the right frontal lobe. Immune Reconstitution Inflammatory Syndrome (IRIS) was suspected, and the patient was treated with methylprednisolone. His clinical symptoms worsened and despite therapy the patient deteriorated.http://dx.doi.org/10.1155/2009/348507 |
| spellingShingle | Peninnah Oberdorfer Charles H. Washington Kamornwan Katanyuwong Podjanee Jittamala Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review International Journal of Pediatrics |
| title | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
| title_full | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
| title_fullStr | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
| title_full_unstemmed | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
| title_short | Progressive Multifocal Leukoencephalopathy in HIV-Infected Children: A Case Report and Literature Review |
| title_sort | progressive multifocal leukoencephalopathy in hiv infected children a case report and literature review |
| url | http://dx.doi.org/10.1155/2009/348507 |
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