Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells

Optimization of lentiviral delivery of barcoded anti-CD20 chimeric antigen receptors into rhesus macaque and human natural killer cells

Natural killer (NK) cells are pivotal in immunosurveillance and hold great potential for immunotherapy due to their ability to target malignant cells. Their low risk of causing graft-versus-host disease (GvHD) post-allogenic transplantation underscores their potential as an off-the shelf cellular th...

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Bibliographic Details
Main Authors: Taha B. Hayal, Aman A. Mulla, David S.J. Allan, Brynn B. Duncan, Saanika Joshi, So Gun Hong, Rafet Basar, Katayoun Rezvani, Richard W. Childs, Chuanfeng Wu, Cynthia E. Dunbar
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
natural killer cell, NK cell
Poloxamer 407
lentiviral transduction
CAR-NK
IL-15
barcode clonal tracking
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050125000683
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