The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury
Abstract Ethnopharmacological relevance Aconitum tanguticum (Maxim.) Stapf (ATS) is a rare Tibetan medicinal plant that belongs to the Ranunculaceae family. This herb is mainly distributed in the high-altitude areas of Qinghai, Gansu provinces, and Tibetan Autonomous Region in China. In Tibetan medi...
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BMC
2025-02-01
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| Series: | Chinese Medicine |
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| Online Access: | https://doi.org/10.1186/s13020-025-01072-7 |
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| author | Xiang Meng Yu-Peng Liu Jia-Wei Dai Yuan Bai Xin Hu Muhammad Azhar Xian-Ju Huang |
| author_facet | Xiang Meng Yu-Peng Liu Jia-Wei Dai Yuan Bai Xin Hu Muhammad Azhar Xian-Ju Huang |
| author_sort | Xiang Meng |
| collection | DOAJ |
| description | Abstract Ethnopharmacological relevance Aconitum tanguticum (Maxim.) Stapf (ATS) is a rare Tibetan medicinal plant that belongs to the Ranunculaceae family. This herb is mainly distributed in the high-altitude areas of Qinghai, Gansu provinces, and Tibetan Autonomous Region in China. In Tibetan medicine, ATS is mainly used to treat lung inflammation, hepatitis, gastrointestinal diseases, influenza, fever caused by infectious diseases, food poisoning, snake and scorpion bites, and yellow water disease. ATS has anti-inflammatory, antiviral, and other pharmacological effects, according to recent research. It is welltolerated by individuals from diverse ethnic groups and has a long history of use in Tibetan medicine. Aim of the study This study investigated the preventive effects of ATS alcoholic extract on acute lung injury (ALI) in mice and aimed to elucidate its possible mechanism of action. Materials and methods Alveolar epithelial cells A549 and specific pathogen-free C57BL/6 mice were induced with lipopolysaccharide (LPS) to establish ALI models both in vivo and in vitro and to explore the pharmacological effects and therapeutic mechanisms of ATS. Results ATS down-regulated the mRNA levels of inflammatory factors NF-κB p65, TNF-α, IL-1β, and IL-8, inhibited the release of reactive oxygen species, inhibited epithelial-mesenchymal transition caused by sustained cell injury, promoted the Keap1/Nrf2/HO-1 signalling pathway, reduced the degree of oxidative stress in vivo, and inhibited the production of proteins associated with LPS-induced ferroptosis. Conclusion The Tibetan medicine ATS reduced pulmonary haemorrhage and oedema in ALI mice, alleviated the degree of lung tissue lesions, inhibited the expression of inflammatory factors and apoptosis, and plays a preventive role against acute lung injury in mice. Graphical Abstract |
| format | Article |
| id | doaj-art-8ef719fdf3bc4742b244ea5aeb24d993 |
| institution | OA Journals |
| issn | 1749-8546 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Chinese Medicine |
| spelling | doaj-art-8ef719fdf3bc4742b244ea5aeb24d9932025-08-20T02:13:02ZengBMCChinese Medicine1749-85462025-02-0120111510.1186/s13020-025-01072-7The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injuryXiang Meng0Yu-Peng Liu1Jia-Wei Dai2Yuan Bai3Xin Hu4Muhammad Azhar5Xian-Ju Huang6College of Pharmaceutical Science, South-Central Minzu UniversityCollege of Pharmaceutical Science, South-Central Minzu UniversityCollege of Pharmaceutical Science, South-Central Minzu UniversityCollege of Pharmaceutical Science, South-Central Minzu UniversityCollege of Pharmaceutical Science, South-Central Minzu UniversityDepartment of Genomics and Bioinformatics, Cholistan University of Vertienary Sciences BahwalpurCollege of Pharmaceutical Science, South-Central Minzu UniversityAbstract Ethnopharmacological relevance Aconitum tanguticum (Maxim.) Stapf (ATS) is a rare Tibetan medicinal plant that belongs to the Ranunculaceae family. This herb is mainly distributed in the high-altitude areas of Qinghai, Gansu provinces, and Tibetan Autonomous Region in China. In Tibetan medicine, ATS is mainly used to treat lung inflammation, hepatitis, gastrointestinal diseases, influenza, fever caused by infectious diseases, food poisoning, snake and scorpion bites, and yellow water disease. ATS has anti-inflammatory, antiviral, and other pharmacological effects, according to recent research. It is welltolerated by individuals from diverse ethnic groups and has a long history of use in Tibetan medicine. Aim of the study This study investigated the preventive effects of ATS alcoholic extract on acute lung injury (ALI) in mice and aimed to elucidate its possible mechanism of action. Materials and methods Alveolar epithelial cells A549 and specific pathogen-free C57BL/6 mice were induced with lipopolysaccharide (LPS) to establish ALI models both in vivo and in vitro and to explore the pharmacological effects and therapeutic mechanisms of ATS. Results ATS down-regulated the mRNA levels of inflammatory factors NF-κB p65, TNF-α, IL-1β, and IL-8, inhibited the release of reactive oxygen species, inhibited epithelial-mesenchymal transition caused by sustained cell injury, promoted the Keap1/Nrf2/HO-1 signalling pathway, reduced the degree of oxidative stress in vivo, and inhibited the production of proteins associated with LPS-induced ferroptosis. Conclusion The Tibetan medicine ATS reduced pulmonary haemorrhage and oedema in ALI mice, alleviated the degree of lung tissue lesions, inhibited the expression of inflammatory factors and apoptosis, and plays a preventive role against acute lung injury in mice. Graphical Abstracthttps://doi.org/10.1186/s13020-025-01072-7Aconitum tanguticum (Maxim.) StapfAcute lung injuryInflammationFerroptosis |
| spellingShingle | Xiang Meng Yu-Peng Liu Jia-Wei Dai Yuan Bai Xin Hu Muhammad Azhar Xian-Ju Huang The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury Chinese Medicine Aconitum tanguticum (Maxim.) Stapf Acute lung injury Inflammation Ferroptosis |
| title | The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury |
| title_full | The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury |
| title_fullStr | The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury |
| title_full_unstemmed | The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury |
| title_short | The preventive effect and mechanism of Tibetan medicine Aconitum tanguticum (Maxim.) Stapf on acute lung injury |
| title_sort | preventive effect and mechanism of tibetan medicine aconitum tanguticum maxim stapf on acute lung injury |
| topic | Aconitum tanguticum (Maxim.) Stapf Acute lung injury Inflammation Ferroptosis |
| url | https://doi.org/10.1186/s13020-025-01072-7 |
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