Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis
Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the follicu...
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| Format: | Article |
| Language: | English |
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IMR Press
2023-07-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007150 |
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| author | Weihuan Hu Yan Wu Yuhang Zhu Fangfang Wang Fan Qu |
| author_facet | Weihuan Hu Yan Wu Yuhang Zhu Fangfang Wang Fan Qu |
| author_sort | Weihuan Hu |
| collection | DOAJ |
| description | Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the folliculogenesis and ovarian steroidogenesis in female rodents. Methods: A search was conducted using EMBASE, PubMed, Web of Science, and Cochrance Library databases. The meta-analyses were performed using mean difference (MD) and random-effects model. Risk of bias and subgroup analyses were assessed using Revman 5.4.1 and R 4.1.2. Registration number: PROSPERO CRD42021292264. Results: A total of 15 studies were included in this systematic review. We found that the exposure of DEHP/MEHP significantly increased the ovary weight (p = 0.003), decreased the serum progesterone levels (p = 0.0008) and delayed the vaginal opening (p = 0.01). Conclusions: The DEHP/MEHP exposure has adverse effects on some aspects of female reproduction ability which tested in female rodent. However, more evidence is needed to strengthen the conclusion. |
| format | Article |
| id | doaj-art-8eef1912d0f44bacb32ea100aca04789 |
| institution | OA Journals |
| issn | 0390-6663 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-8eef1912d0f44bacb32ea100aca047892025-08-20T02:09:21ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632023-07-0150715010.31083/j.ceog5007150S0390-6663(23)02068-7Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-AnalysisWeihuan Hu0Yan Wu1Yuhang Zhu2Fangfang Wang3Fan Qu4Department of Chinese Integrative Medicine, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaDepartment of Chinese Integrative Medicine, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaDepartment of Chinese Integrative Medicine, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaDepartment of Chinese Integrative Medicine, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaDepartment of Chinese Integrative Medicine, Women's Hospital, School of Medicine, Zhejiang University, 310006 Hangzhou, Zhejiang, ChinaBackground: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the folliculogenesis and ovarian steroidogenesis in female rodents. Methods: A search was conducted using EMBASE, PubMed, Web of Science, and Cochrance Library databases. The meta-analyses were performed using mean difference (MD) and random-effects model. Risk of bias and subgroup analyses were assessed using Revman 5.4.1 and R 4.1.2. Registration number: PROSPERO CRD42021292264. Results: A total of 15 studies were included in this systematic review. We found that the exposure of DEHP/MEHP significantly increased the ovary weight (p = 0.003), decreased the serum progesterone levels (p = 0.0008) and delayed the vaginal opening (p = 0.01). Conclusions: The DEHP/MEHP exposure has adverse effects on some aspects of female reproduction ability which tested in female rodent. However, more evidence is needed to strengthen the conclusion.https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007150systematic reviewdiethylhexyl phthalate (dehp)mono(2-ethylhexyl) phthalate (mehp)folliculogenesisovarian steroidogenesisestradiolprogesteronemeta-analysis |
| spellingShingle | Weihuan Hu Yan Wu Yuhang Zhu Fangfang Wang Fan Qu Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis Clinical and Experimental Obstetrics & Gynecology systematic review diethylhexyl phthalate (dehp) mono(2-ethylhexyl) phthalate (mehp) folliculogenesis ovarian steroidogenesis estradiol progesterone meta-analysis |
| title | Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis |
| title_full | Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis |
| title_fullStr | Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis |
| title_short | Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis |
| title_sort | association between diethylhexyl phthalate exposure with folliculogenesis and ovarian steroidogenesis a systematic review and meta analysis |
| topic | systematic review diethylhexyl phthalate (dehp) mono(2-ethylhexyl) phthalate (mehp) folliculogenesis ovarian steroidogenesis estradiol progesterone meta-analysis |
| url | https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007150 |
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