Association between Diethylhexyl Phthalate Exposure with Folliculogenesis and Ovarian Steroidogenesis: A Systematic Review and Meta-Analysis
Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the follicu...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2023-07-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/CEOG/50/7/10.31083/j.ceog5007150 |
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| Summary: | Background: Environmental endocrine disruptor-diethylhexyl phthalate (DEHP) or its active metabolites-mono(2-ethylhexyl) phthalate (MEHP) has the greatest endocrine disrupting potency. The present systematic review and meta-analysis was to investigate the effects of DEHP/MEHP exposure on the folliculogenesis and ovarian steroidogenesis in female rodents. Methods: A search was conducted using EMBASE, PubMed, Web of Science, and Cochrance Library databases. The meta-analyses were performed using mean difference (MD) and random-effects model. Risk of bias and subgroup analyses were assessed using Revman 5.4.1 and R 4.1.2. Registration number: PROSPERO CRD42021292264. Results: A total of 15 studies were included in this systematic review. We found that the exposure of DEHP/MEHP significantly increased the ovary weight (p = 0.003), decreased the serum progesterone levels (p = 0.0008) and delayed the vaginal opening (p = 0.01). Conclusions: The DEHP/MEHP exposure has adverse effects on some aspects of female reproduction ability which tested in female rodent. However, more evidence is needed to strengthen the conclusion. |
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| ISSN: | 0390-6663 |