Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center
Background: Complicated skin and soft tissue infections often lead to poor health outcomes, with necrotizing skin and soft tissue infections occurring in 70%–80% of hospitalized patients and a mortality rate typically exceeding 20%. The current study’s main objective was to identify early predictors...
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SAGE Publishing
2025-04-01
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| Series: | SAGE Open Medicine |
| Online Access: | https://doi.org/10.1177/20503121251336069 |
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| author | Haifa M. Algethamy Rufaydah Nasser Alhazmi Firyal Kamal Alghalayini Sarah Yasir Bahowarth Nirmeen M. Bukhari Layan Bandar Alnosani Samaher Khalid Dubaei Razan Abdulelah Sait Raghad Abdulaziz Mulla Yasser Abdelghaffar Own Adel M. Alshabasy |
| author_facet | Haifa M. Algethamy Rufaydah Nasser Alhazmi Firyal Kamal Alghalayini Sarah Yasir Bahowarth Nirmeen M. Bukhari Layan Bandar Alnosani Samaher Khalid Dubaei Razan Abdulelah Sait Raghad Abdulaziz Mulla Yasser Abdelghaffar Own Adel M. Alshabasy |
| author_sort | Haifa M. Algethamy |
| collection | DOAJ |
| description | Background: Complicated skin and soft tissue infections often lead to poor health outcomes, with necrotizing skin and soft tissue infections occurring in 70%–80% of hospitalized patients and a mortality rate typically exceeding 20%. The current study’s main objective was to identify early predictors of sepsis, intensive care unit admission, and mortality in hospitalized complicated skin and soft tissue infection patients. Methods: A retrospective review of records from 235 adult complicated skin and soft tissue infection patients admitted from 2012 to 2022 was conducted. Collected data included demographics, medical history, clinical presentation, treatment, and outcomes. Laboratory results were used to calculate the Laboratory Risk Indicator for Necrotizing Fasciitis score for diagnosing necrotizing fasciitis. Predictors of sepsis, intensive care unit admission, and death were identified using logistic regression analysis. Results: Of the 235 patients, 42.1% were wheelchair-bound or bedridden; 93.2% had diabetes, 76.2% had cardiovascular disease, and 33.6% had kidney disease. Necrotizing fasciitis criteria were met by 75% of patients. Sepsis was diagnosed in 27.7% of patients, while 30.6% required intensive care unit admission, and 20.4% did not survive hospital discharge. Low mean arterial pressure and vasopressor use were significant predictors of all three severe outcomes, with pre-existing kidney disease also a predictor of in-hospital death. The Glasgow Coma Scale predicted both intensive care unit admission and sepsis, but not death. Conclusions: Low mean arterial pressure, vasopressor use, and pre-existing kidney disease are key predictors of in-hospital death in patients hospitalized for complicated skin and soft tissue infection. The former two, and the patient’s Glasgow Coma Scale, also appear to predict both intensive care unit admission and sepsis. |
| format | Article |
| id | doaj-art-8eed30c8e66b4eecacd403482eee9542 |
| institution | DOAJ |
| issn | 2050-3121 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | SAGE Open Medicine |
| spelling | doaj-art-8eed30c8e66b4eecacd403482eee95422025-08-20T03:14:01ZengSAGE PublishingSAGE Open Medicine2050-31212025-04-011310.1177/20503121251336069Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care centerHaifa M. Algethamy0Rufaydah Nasser Alhazmi1Firyal Kamal Alghalayini2Sarah Yasir Bahowarth3Nirmeen M. Bukhari4Layan Bandar Alnosani5Samaher Khalid Dubaei6Razan Abdulelah Sait7Raghad Abdulaziz Mulla8Yasser Abdelghaffar Own9Adel M. Alshabasy10Faculty of Medicine, Department of Anaesthesia and Critical Care, King Abdulaziz University, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaFaculty of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaDepartment of Anaesthesia and Critical Care, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaDepartment of Anaesthesia and Critical Care, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaBackground: Complicated skin and soft tissue infections often lead to poor health outcomes, with necrotizing skin and soft tissue infections occurring in 70%–80% of hospitalized patients and a mortality rate typically exceeding 20%. The current study’s main objective was to identify early predictors of sepsis, intensive care unit admission, and mortality in hospitalized complicated skin and soft tissue infection patients. Methods: A retrospective review of records from 235 adult complicated skin and soft tissue infection patients admitted from 2012 to 2022 was conducted. Collected data included demographics, medical history, clinical presentation, treatment, and outcomes. Laboratory results were used to calculate the Laboratory Risk Indicator for Necrotizing Fasciitis score for diagnosing necrotizing fasciitis. Predictors of sepsis, intensive care unit admission, and death were identified using logistic regression analysis. Results: Of the 235 patients, 42.1% were wheelchair-bound or bedridden; 93.2% had diabetes, 76.2% had cardiovascular disease, and 33.6% had kidney disease. Necrotizing fasciitis criteria were met by 75% of patients. Sepsis was diagnosed in 27.7% of patients, while 30.6% required intensive care unit admission, and 20.4% did not survive hospital discharge. Low mean arterial pressure and vasopressor use were significant predictors of all three severe outcomes, with pre-existing kidney disease also a predictor of in-hospital death. The Glasgow Coma Scale predicted both intensive care unit admission and sepsis, but not death. Conclusions: Low mean arterial pressure, vasopressor use, and pre-existing kidney disease are key predictors of in-hospital death in patients hospitalized for complicated skin and soft tissue infection. The former two, and the patient’s Glasgow Coma Scale, also appear to predict both intensive care unit admission and sepsis.https://doi.org/10.1177/20503121251336069 |
| spellingShingle | Haifa M. Algethamy Rufaydah Nasser Alhazmi Firyal Kamal Alghalayini Sarah Yasir Bahowarth Nirmeen M. Bukhari Layan Bandar Alnosani Samaher Khalid Dubaei Razan Abdulelah Sait Raghad Abdulaziz Mulla Yasser Abdelghaffar Own Adel M. Alshabasy Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center SAGE Open Medicine |
| title | Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center |
| title_full | Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center |
| title_fullStr | Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center |
| title_full_unstemmed | Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center |
| title_short | Predictors of sepsis, intensive care unit admission, and death in patients hospitalized for complicated skin and soft tissue infections: Retrospective study at a large tertiary-care center |
| title_sort | predictors of sepsis intensive care unit admission and death in patients hospitalized for complicated skin and soft tissue infections retrospective study at a large tertiary care center |
| url | https://doi.org/10.1177/20503121251336069 |
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