Association of left atrial strain and inflammatory factors in hypertensive patients working in the Arctic
Aim. To study the association of left atrial (LA) strain and inflammatory factors in hypertensive (HTN) patients without target organ damage working on a rotational basis in the Arctic.Material and methods. A total of 335 patients were recruited in 20222023 at the Novy Port of OOO Gazpromneft-Yamal,...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2025-07-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/4277 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Aim. To study the association of left atrial (LA) strain and inflammatory factors in hypertensive (HTN) patients without target organ damage working on a rotational basis in the Arctic.Material and methods. A total of 335 patients were recruited in 20222023 at the Novy Port of OOO Gazpromneft-Yamal, located in the Arctic. The study included 86 patients with HTN and healthy individuals aged 1860 years working by the expeditionary shifts. Inflammatory markers such as interleukin (IL)-1b, IL-6, IL-8, tumor necrosis factor alpha (TNF-a), high-sensitivity C-reactive protein (hsCRP) were determined in the blood serum. We performed transthoracic speckle tracking echocardiography to assess the left atrial reservoir strain (LASr) on the Vivid S70 device, USA, and determination of tissue color Doppler indices.Results. All patients included in the study were divided into 2 groups: Group 1 — 49 patients with stage 1 hypertension, mainly men (89,8%), middle-aged (45,07±8,1 years), group 2 — 37 practically healthy individuals, the average age was 43,24±7,6 years, men 86,5%. In the group of hypertensive patients, a subgroup of patients with a decrease in LASr compared to the reference index (<39%) and with an increase in LASr (>39%) was identified. There were no patients with LASr ≲23%, which allowed us to rule out heart failure. About half of the patients with HTN had LASr between 23 and 39%. The levels of proinflammatory cytokines (IL-1, IL-6, IL-8) in patients with HTN did not differ from the parameters of healthy individuals. Early diastolic lateral and septal mitral annular velocities (TDI e'lat and TDI e'sept) were significantly lower in the Arctic conditions compared to those in healthy individuals. The correlations between the LA strain and cytokines were studied. An inversely proportional correlation was found between the TDI e'lat and TDI e'sept parameters and the IL-6 level.Conclusion. Analysis of a subgroup of patients with HTNwithout left ventricular hypertrophy showed an inversely proportional relationship between the cytokine and TDI e'lat and TDI e'sept levels, which suggests an association of inflammatory factors and LA strain in patients with HTN working on a rotational basis in the Arctic. |
|---|---|
| ISSN: | 1728-8800 2619-0125 |