Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus

Interferon activation in bone marrow long-lived plasma cells in systemic lupus erythematosus

While durable antibody responses from long-lived plasma cell (LLPC) populations are important for protection against pathogens, LLPC may be harmful if they produce antibodies against self-proteins or self-nuclear antigens as occurs in autoimmune diseases such as systemic lupus erythematosus (SLE). T...

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Bibliographic Details
Main Authors: Diana F. Alzamareh, Nida Meednu, Neha Nandedkar-Kulkarni, Daria Krenitsky, Jennifer Barnard, Ken Yasaka, Wesley Durrett, Juilee Thakar, Javier Rangel-Moreno, Jennifer H. Anolik, Jennifer L. Barnas
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
plasma cell (PC)
lupus (SLE)
transitional B cell
bone marrow
interferon
B cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1499551/full
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