Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging
This paper aims to investigate the dielectric properties of blood for tumor detection and staging. The application of complex thermodynamic models and the study of the trend over time of some thermodynamic functions have allowed us to highlight the generation of displacement currents caused by chang...
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MDPI AG
2025-05-01
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| Online Access: | https://www.mdpi.com/2079-7737/14/5/542 |
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| author | Annamaria Russo Ester Tellone Francesco Farsaci |
| author_facet | Annamaria Russo Ester Tellone Francesco Farsaci |
| author_sort | Annamaria Russo |
| collection | DOAJ |
| description | This paper aims to investigate the dielectric properties of blood for tumor detection and staging. The application of complex thermodynamic models and the study of the trend over time of some thermodynamic functions have allowed us to highlight the generation of displacement currents caused by changes in charge, i.e., by the activation and consequent accumulation of platelets on migrating tumor cells. Although few studies exist to date in this regard, the technique used has provided promising results, especially in terms of building a database. In this context, the evaluation of the dielectric parameters of healthy and cancerous blood can be exploited for the staging of cancer. The main advantages of this method include easy application, non-invasiveness, low cost, and online monitoring. |
| format | Article |
| id | doaj-art-8edf0eeebd634e858ffaa13a35df27af |
| institution | Kabale University |
| issn | 2079-7737 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj-art-8edf0eeebd634e858ffaa13a35df27af2025-08-20T03:47:48ZengMDPI AGBiology2079-77372025-05-0114554210.3390/biology14050542Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and StagingAnnamaria Russo0Ester Tellone1Francesco Farsaci2Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, ItalyDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale Ferdinando Stagno d’Alcontres 31, 98166 Messina, ItalyThis paper aims to investigate the dielectric properties of blood for tumor detection and staging. The application of complex thermodynamic models and the study of the trend over time of some thermodynamic functions have allowed us to highlight the generation of displacement currents caused by changes in charge, i.e., by the activation and consequent accumulation of platelets on migrating tumor cells. Although few studies exist to date in this regard, the technique used has provided promising results, especially in terms of building a database. In this context, the evaluation of the dielectric parameters of healthy and cancerous blood can be exploited for the staging of cancer. The main advantages of this method include easy application, non-invasiveness, low cost, and online monitoring.https://www.mdpi.com/2079-7737/14/5/542non-equilibrium thermodynamicscancercirculating tumor cellsplateletstumor staging |
| spellingShingle | Annamaria Russo Ester Tellone Francesco Farsaci Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging Biology non-equilibrium thermodynamics cancer circulating tumor cells platelets tumor staging |
| title | Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging |
| title_full | Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging |
| title_fullStr | Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging |
| title_full_unstemmed | Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging |
| title_short | Exploring Tumor Cell–Platelet Biochemical Interactions by Dielectric Measurements of Blood: A Potential Target for Tumor Detection and Staging |
| title_sort | exploring tumor cell platelet biochemical interactions by dielectric measurements of blood a potential target for tumor detection and staging |
| topic | non-equilibrium thermodynamics cancer circulating tumor cells platelets tumor staging |
| url | https://www.mdpi.com/2079-7737/14/5/542 |
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