Erase the trace: new frontiers in scar prevention and skin repair
The management of scarring continues to be significant in health care due to their ubiquity and impact on daily life. Scars include immature, mature, atrophic, hypertrophic, and keloid scars, with hypertrophic and keloid scars commonly being targeted for therapeutic interventions. Hypertrophic and k...
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| Format: | Article |
| Language: | English |
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ELS Publishing (ELSP)
2024-11-01
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| Series: | Biofunctional Materials |
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| Online Access: | https://elsp-homepage.oss-cn-hongkong.aliyuncs.compaper/journal/open/BM/2024/BM-24080023-bm20240009.pdf |
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| author | Shi Fu Niharika Singh Shiffoni Sukhlal Huiting Luo Divleen K. Singh Mimi R Borrelli Duc Bui Sami Khan Alexander B. Dagum Gurtej Singh |
| author_facet | Shi Fu Niharika Singh Shiffoni Sukhlal Huiting Luo Divleen K. Singh Mimi R Borrelli Duc Bui Sami Khan Alexander B. Dagum Gurtej Singh |
| author_sort | Shi Fu |
| collection | DOAJ |
| description | The management of scarring continues to be significant in health care due to their ubiquity and impact on daily life. Scars include immature, mature, atrophic, hypertrophic, and keloid scars, with hypertrophic and keloid scars commonly being targeted for therapeutic interventions. Hypertrophic and keloid scars have dysregulated wound healing phases, involving higher levels of inflammatory markers, such as TGF-β, PDGF, VEGF, as well as increased type 1 collagen. Current treatments for hypertrophic scarring and keloid scars include pressure garments, corticosteroids, laser therapy, scar excision, and radiation. The next steps in therapy involve minimizing scars and eventually eliminating scars by tissue regeneration; current research is exploring the inhibition of Yes-associated protein and harnessing TGF-β3 to support tissue regeneration over scarring in humans. |
| format | Article |
| id | doaj-art-8edd7d1e5ad948c9840edbcb6bf79b5a |
| institution | DOAJ |
| issn | 2959-0574 2959-0582 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | ELS Publishing (ELSP) |
| record_format | Article |
| series | Biofunctional Materials |
| spelling | doaj-art-8edd7d1e5ad948c9840edbcb6bf79b5a2025-08-20T03:07:28ZengELS Publishing (ELSP)Biofunctional Materials2959-05742959-05822024-11-012210.55092/bm202400091823712974041604096Erase the trace: new frontiers in scar prevention and skin repairShi Fu0Niharika Singh1Shiffoni Sukhlal2Huiting Luo3Divleen K. Singh4Mimi R Borrelli5Duc Bui6Sami Khan7Alexander B. Dagum8Gurtej Singh9Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA Department of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USADepartment of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA Department of Materials Science and Chemical Engineering, Stony Brook University, Stony Brook, New York, USA Department of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USADepartment of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USADepartment of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USADepartment of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USADepartment of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USADepartment of Surgery, Stony Brook University Hospital, Stony Brook University, Stony Brook, New York, USAThe management of scarring continues to be significant in health care due to their ubiquity and impact on daily life. Scars include immature, mature, atrophic, hypertrophic, and keloid scars, with hypertrophic and keloid scars commonly being targeted for therapeutic interventions. Hypertrophic and keloid scars have dysregulated wound healing phases, involving higher levels of inflammatory markers, such as TGF-β, PDGF, VEGF, as well as increased type 1 collagen. Current treatments for hypertrophic scarring and keloid scars include pressure garments, corticosteroids, laser therapy, scar excision, and radiation. The next steps in therapy involve minimizing scars and eventually eliminating scars by tissue regeneration; current research is exploring the inhibition of Yes-associated protein and harnessing TGF-β3 to support tissue regeneration over scarring in humans.https://elsp-homepage.oss-cn-hongkong.aliyuncs.compaper/journal/open/BM/2024/BM-24080023-bm20240009.pdfscarsscar preventionskin regeneration |
| spellingShingle | Shi Fu Niharika Singh Shiffoni Sukhlal Huiting Luo Divleen K. Singh Mimi R Borrelli Duc Bui Sami Khan Alexander B. Dagum Gurtej Singh Erase the trace: new frontiers in scar prevention and skin repair Biofunctional Materials scars scar prevention skin regeneration |
| title | Erase the trace: new frontiers in scar prevention and skin repair |
| title_full | Erase the trace: new frontiers in scar prevention and skin repair |
| title_fullStr | Erase the trace: new frontiers in scar prevention and skin repair |
| title_full_unstemmed | Erase the trace: new frontiers in scar prevention and skin repair |
| title_short | Erase the trace: new frontiers in scar prevention and skin repair |
| title_sort | erase the trace new frontiers in scar prevention and skin repair |
| topic | scars scar prevention skin regeneration |
| url | https://elsp-homepage.oss-cn-hongkong.aliyuncs.compaper/journal/open/BM/2024/BM-24080023-bm20240009.pdf |
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