Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota
Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymeth...
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Tsinghua University Press
2023-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453023000125 |
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| author | Tao Wang Panpan Wang Li Yin Xiuchao Wang Yuanyuan Shan Yanglei Yi Yuan Zhou Bianfang Liu Xin Wang Xin Lü |
| author_facet | Tao Wang Panpan Wang Li Yin Xiuchao Wang Yuanyuan Shan Yanglei Yi Yuan Zhou Bianfang Liu Xin Wang Xin Lü |
| author_sort | Tao Wang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress. |
| format | Article |
| id | doaj-art-8edd6c9a93964f4aa96efb37fa233418 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Tsinghua University Press |
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| series | Food Science and Human Wellness |
| spelling | doaj-art-8edd6c9a93964f4aa96efb37fa2334182025-02-03T00:27:37ZengTsinghua University PressFood Science and Human Wellness2213-45302023-09-0112516261636Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiotaTao Wang0Panpan Wang1Li Yin2Xiuchao Wang3Yuanyuan Shan4Yanglei Yi5Yuan Zhou6Bianfang Liu7Xin Wang8Xin Lü9College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, China; Faculty of Food Science and Engineering, Kunming University of Science and Technology, Kunming 650500, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, China; Corresponding authors at: College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, China; Corresponding authors at: College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaCollege of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, China; Corresponding authors at: College of Food Science and Engineering, Northwest Agriculture and Forestry University, Yangling 712100, ChinaColorectal cancer (CRC) is one of the most common cancers and supplementation of probiotics may be a promising intervention method. The present study aimed to investigate the anti-CRC effects of Lactiplantibacillus plantarum KX041 on a CRC mouse model. The CRC mice were induced by 10 mg/kg azoxymethane and 2 % dextran sulfate sodium. L. plantarum KX041 was orally administrated once daily (1 × 109 CFU/mouse). Results showed that L. plantarum KX041 could significantly inhibit inflammation, tumor formation, and induce tumor cells apoptosis. Moreover, this probiotic could ameliorate the damage of intestinal barrier by recovering tight junction protein expression (like Occludin, Claudin-1, and ZO-1) and preventing goblet cell loss. Furthermore, the oxidative stress was alleviated by increasing the level of antioxidant mediators (like GSH and SOD) and reducing the level of oxidative mediators (like MDA and MPO). In addition, treatment with L. plantarum KX041 could directly regulate gut microbiota, thereby increasing the abundance of beneficial bacteria (like SCFAs-producing bacteria, Akkermansia) and decreasing the abundance of harmful bacteria (like pro-inflammatory bacteria, Parasutterella), which in turn raised SCFAs levels and lowered LPS levels. In conclusion, L. plantarum KX041 could effectively ameliorate CRC via reshaping intestinal microenvironment, alleviating inflammation, maintaining intestinal permeability, and attenuating oxidative stress.http://www.sciencedirect.com/science/article/pii/S2213453023000125Lactiplantibacillus plantarum KX041Colorectal cancerGut microbiotaInflammationIntestinal permeability |
| spellingShingle | Tao Wang Panpan Wang Li Yin Xiuchao Wang Yuanyuan Shan Yanglei Yi Yuan Zhou Bianfang Liu Xin Wang Xin Lü Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota Food Science and Human Wellness Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability |
| title | Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota |
| title_full | Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota |
| title_fullStr | Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota |
| title_full_unstemmed | Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota |
| title_short | Dietary Lactiplantibacillus plantarum KX041 attenuates colitis-associated tumorigenesis and modulates gut microbiota |
| title_sort | dietary lactiplantibacillus plantarum kx041 attenuates colitis associated tumorigenesis and modulates gut microbiota |
| topic | Lactiplantibacillus plantarum KX041 Colorectal cancer Gut microbiota Inflammation Intestinal permeability |
| url | http://www.sciencedirect.com/science/article/pii/S2213453023000125 |
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