Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury
Coadministering two different classes of antibiotics as empirical therapy can be critical in treating healthcare-associated infections in hospitals. Herein, we report a case of acute kidney injury (AKI) caused by coadministration of vancomycin with high-dose meropenem that manifested as a rapid incr...
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2024/7956014 |
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| _version_ | 1832559705700958208 |
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| author | Yoshiro Sakai Seiji Karakawa Takato Koutaki Kyoko Higuchi Aya Hashimoto Hiroshi Watanabe |
| author_facet | Yoshiro Sakai Seiji Karakawa Takato Koutaki Kyoko Higuchi Aya Hashimoto Hiroshi Watanabe |
| author_sort | Yoshiro Sakai |
| collection | DOAJ |
| description | Coadministering two different classes of antibiotics as empirical therapy can be critical in treating healthcare-associated infections in hospitals. Herein, we report a case of acute kidney injury (AKI) caused by coadministration of vancomycin with high-dose meropenem that manifested as a rapid increase in serum creatinine levels and an associated increase in vancomycin trough concentrations. The patient was diagnosed with meningioma at 50 years and was followed up regularly. The patient underwent surgery and antibiotic treatment between 63 and 66 years for suspected meningitis and pneumonia. Coadministration of vancomycin with high-dose meropenem (6.0 g/day) caused AKI; however, no AKI occurred when vancomycin was administered alone or with a low dose of meropenem (1.5 or 3.0 g/day). To our knowledge, this report is the first to show that administering different dosages of meropenem in combination with vancomycin may contribute to the risk of developing AKI. We suggest that coadministered vancomycin and high-dose meropenem (6.0 g/day) may increase the risk of AKI. Our report adds to the limited literature documenting the coadministration of vancomycin with varying doses of meropenem and its impact on the risk of AKI and highlights the importance of investigating AKI risk in response to varying dosages of meropenem when it is coadministered with vancomycin. |
| format | Article |
| id | doaj-art-8edaa07c10784e8092c66bd8ee487d39 |
| institution | Kabale University |
| issn | 2090-6633 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-8edaa07c10784e8092c66bd8ee487d392025-02-03T01:29:29ZengWileyCase Reports in Infectious Diseases2090-66332024-01-01202410.1155/2024/7956014Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney InjuryYoshiro Sakai0Seiji Karakawa1Takato Koutaki2Kyoko Higuchi3Aya Hashimoto4Hiroshi Watanabe5Department of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyDepartment of NeurosurgeryDepartment of Infection Control and PreventionCoadministering two different classes of antibiotics as empirical therapy can be critical in treating healthcare-associated infections in hospitals. Herein, we report a case of acute kidney injury (AKI) caused by coadministration of vancomycin with high-dose meropenem that manifested as a rapid increase in serum creatinine levels and an associated increase in vancomycin trough concentrations. The patient was diagnosed with meningioma at 50 years and was followed up regularly. The patient underwent surgery and antibiotic treatment between 63 and 66 years for suspected meningitis and pneumonia. Coadministration of vancomycin with high-dose meropenem (6.0 g/day) caused AKI; however, no AKI occurred when vancomycin was administered alone or with a low dose of meropenem (1.5 or 3.0 g/day). To our knowledge, this report is the first to show that administering different dosages of meropenem in combination with vancomycin may contribute to the risk of developing AKI. We suggest that coadministered vancomycin and high-dose meropenem (6.0 g/day) may increase the risk of AKI. Our report adds to the limited literature documenting the coadministration of vancomycin with varying doses of meropenem and its impact on the risk of AKI and highlights the importance of investigating AKI risk in response to varying dosages of meropenem when it is coadministered with vancomycin.http://dx.doi.org/10.1155/2024/7956014 |
| spellingShingle | Yoshiro Sakai Seiji Karakawa Takato Koutaki Kyoko Higuchi Aya Hashimoto Hiroshi Watanabe Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury Case Reports in Infectious Diseases |
| title | Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury |
| title_full | Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury |
| title_fullStr | Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury |
| title_full_unstemmed | Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury |
| title_short | Concomitant Administration of Vancomycin with a High Dose of Meropenem May Cause Acute Kidney Injury |
| title_sort | concomitant administration of vancomycin with a high dose of meropenem may cause acute kidney injury |
| url | http://dx.doi.org/10.1155/2024/7956014 |
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