Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT

Eradication of Helicobacter pylori for prevention of aspirin-associated peptic ulcer bleeding in adults over 65 years: the HEAT RCT

Background Peptic ulcers in patients on aspirin are associated with Helicobacter pylori infection. We investigated whether H. pylori eradication would protect against aspirin-associated ulcer bleeding. Methods The Helicobacter Eradication Aspirin Trial was a randomised placebo-controlled trial (Euro...

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Bibliographic Details
Main Authors: CJ Hawkey, Anthony J Avery, Carol AC Coupland, Colin J Crooks, Jennifer S Dumbleton, FD Richard Hobbs, Denise Kendrick, Michael Moore, Clive Morris, Gregory Rubin, Murray Smith, Diane Stevenson
Format: Article
Language:English
Published: NIHR Journals Library 2025-08-01
Series:Health Technology Assessment
Subjects:
helicobacter pylori
aspirin
c13 urea breath test
lansoprazole
clarithromycin
metronidazole
peptic ulcer
peptic ulcer haemorrhage
gastrointestinal haemorrhage
dyspepsia
primary care
consultation and referral
hospitalisation
death
intention-to-treat analysis
follow-up studies
randomised controlled trial
outcomes study
Online Access:https://doi.org/10.3310/LLKF7871
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