The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies
The review deals with the results of clinical and experimental studies of the original Russian drug glyciphon used to treat basal cell carcinoma (BCC). Glyciphon is diglycidyl ether of methylphosphonic acid, which has been synthesized at the A. E. Arbuzov Institute of Organic and Physical Chemistry,...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2015-11-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/169 |
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| author | L. N. Zalyalyutdinova R. S. Garaev |
| author_facet | L. N. Zalyalyutdinova R. S. Garaev |
| author_sort | L. N. Zalyalyutdinova |
| collection | DOAJ |
| description | The review deals with the results of clinical and experimental studies of the original Russian drug glyciphon used to treat basal cell carcinoma (BCC). Glyciphon is diglycidyl ether of methylphosphonic acid, which has been synthesized at the A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, belongs to a class of organophosphors epoxides. The drug has been experimentally tested by Kazan scientists who revealed the selectivity of its antiblastoma activity, relatively low toxicity, and high safety when it was used long. The antiproliferatve activity of glyciphon in inhibiting DNA synthesis, retarding all mitotic phases, and blocking the entry of cells into S and M phases plays an important role in its mechanism of antiblastoma action. Glyciphon ointment 30 % is effective in the treatment of primary BCC (solitary tumors and polyneoplasms) and its recurrences after radiation and surgery in the absence of a side skin resorption effect. It may be successfully used to treat BCC that are refractory to radiotherapy and surgical dissection and to detect latent foci of multiple BCC. The ointment is registered as an agent for the treatment of Stage I squamous cell carcinoma, as well as basaliomas (including recurrences after surgery and radiotherapy), Bowen,s disease, senile keratosis. Glyciphon is manufactured by OAO “Tatchempharmpreparaty” (Kazan) (as 30 % ointment from the substance made by the affiliate of the A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences. |
| format | Article |
| id | doaj-art-8ed291d4f9594cd7a851ee8cea5309d4 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2015-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj-art-8ed291d4f9594cd7a851ee8cea5309d42025-08-20T03:37:51ZrusABV-pressОпухоли головы и шеи2222-14682411-46342015-11-0153313810.17650/2222-1468-2015-5-3-31-38161The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studiesL. N. Zalyalyutdinova0R. S. Garaev1Kazan State Medical University, Ministry of Health of Russia; 49 Butlerov St., Kazan, 420012, RussiaKazan State Medical University, Ministry of Health of Russia; 49 Butlerov St., Kazan, 420012, RussiaThe review deals with the results of clinical and experimental studies of the original Russian drug glyciphon used to treat basal cell carcinoma (BCC). Glyciphon is diglycidyl ether of methylphosphonic acid, which has been synthesized at the A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences, belongs to a class of organophosphors epoxides. The drug has been experimentally tested by Kazan scientists who revealed the selectivity of its antiblastoma activity, relatively low toxicity, and high safety when it was used long. The antiproliferatve activity of glyciphon in inhibiting DNA synthesis, retarding all mitotic phases, and blocking the entry of cells into S and M phases plays an important role in its mechanism of antiblastoma action. Glyciphon ointment 30 % is effective in the treatment of primary BCC (solitary tumors and polyneoplasms) and its recurrences after radiation and surgery in the absence of a side skin resorption effect. It may be successfully used to treat BCC that are refractory to radiotherapy and surgical dissection and to detect latent foci of multiple BCC. The ointment is registered as an agent for the treatment of Stage I squamous cell carcinoma, as well as basaliomas (including recurrences after surgery and radiotherapy), Bowen,s disease, senile keratosis. Glyciphon is manufactured by OAO “Tatchempharmpreparaty” (Kazan) (as 30 % ointment from the substance made by the affiliate of the A. E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Research Center, Russian Academy of Sciences.https://ogsh.abvpress.ru/jour/article/view/169glyciphonglyciphon ointment 30 %basal cell carcinomasquamous cell carcinoma polyneoplasmsrecurrent tumorsantiblastoma actionradiotherapysurgical treatmentorganophosphorus epoxides |
| spellingShingle | L. N. Zalyalyutdinova R. S. Garaev The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies Опухоли головы и шеи glyciphon glyciphon ointment 30 % basal cell carcinoma squamous cell carcinoma polyneoplasms recurrent tumors antiblastoma action radiotherapy surgical treatment organophosphorus epoxides |
| title | The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies |
| title_full | The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies |
| title_fullStr | The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies |
| title_full_unstemmed | The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies |
| title_short | The Russian drug glyciphon, a representative of organophosphorus epoxides, for the treatment of basal cell carcinoma – clinical and experimental studies |
| title_sort | russian drug glyciphon a representative of organophosphorus epoxides for the treatment of basal cell carcinoma clinical and experimental studies |
| topic | glyciphon glyciphon ointment 30 % basal cell carcinoma squamous cell carcinoma polyneoplasms recurrent tumors antiblastoma action radiotherapy surgical treatment organophosphorus epoxides |
| url | https://ogsh.abvpress.ru/jour/article/view/169 |
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