Gut–Adipose Tissue Axis and Metabolic Health
The gut–adipose tissue axis plays a crucial role in metabolic health. It is a two-way communication pathway between the gastrointestinal tract and adipose tissue. This axis influences physiological processes vital for maintaining metabolic health, including energy homeostasis, lipid metabolism, and...
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| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Current Issues in Molecular Biology |
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| Online Access: | https://www.mdpi.com/1467-3045/47/6/424 |
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| author | Sanja Borozan Cornelius J. Fernandez Adnan Samee Joseph M. Pappachan |
| author_facet | Sanja Borozan Cornelius J. Fernandez Adnan Samee Joseph M. Pappachan |
| author_sort | Sanja Borozan |
| collection | DOAJ |
| description | The gut–adipose tissue axis plays a crucial role in metabolic health. It is a two-way communication pathway between the gastrointestinal tract and adipose tissue. This axis influences physiological processes vital for maintaining metabolic health, including energy homeostasis, lipid metabolism, and inflammation. Emerging research suggests that the gut microbiota, composed of trillions of microorganisms residing in the intestines, significantly impacts this axis by modulating host metabolism. An imbalance in the gut microbiota (dysbiosis) has been linked to obesity, insulin resistance, and other metabolic disorders. Innovative therapeutic strategies and dietary interventions aimed at modulating the gut–adipose tissue axis have shown encouraging results in improving metabolic health. A deeper critical understanding of the gut–adipose tissue axis is, therefore, essential in understanding the pathophysiology of metabolic disorders so that targeted interventions can be developed to prevent and treat these metabolic disorders. This article highlights the need for integrative approaches that consider both gastrointestinal and adipose functions in metabolic health management. |
| format | Article |
| id | doaj-art-8ed126057ffc48e4913acc90a28c8ce2 |
| institution | Kabale University |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Issues in Molecular Biology |
| spelling | doaj-art-8ed126057ffc48e4913acc90a28c8ce22025-08-20T03:26:11ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452025-06-0147642410.3390/cimb47060424Gut–Adipose Tissue Axis and Metabolic HealthSanja Borozan0Cornelius J. Fernandez1Adnan Samee2Joseph M. Pappachan3Department of Endocrinology, Clinical Centre of Montenegro, Faculty of Medicine, 81000 Podgorica, MontenegroDepartment of Endocrinology and Metabolism, Pilgrim Hospital, United Lincolnshire Hospitals NHS Trust, Boston PE21 9QS, UKDepartment of Medicine, Royal Stoke University Hospital, Stoke-on-Trent ST4 6QG, UKFaculty of Science, Manchester Metropolitan University, Manchester M15 6BH, UKThe gut–adipose tissue axis plays a crucial role in metabolic health. It is a two-way communication pathway between the gastrointestinal tract and adipose tissue. This axis influences physiological processes vital for maintaining metabolic health, including energy homeostasis, lipid metabolism, and inflammation. Emerging research suggests that the gut microbiota, composed of trillions of microorganisms residing in the intestines, significantly impacts this axis by modulating host metabolism. An imbalance in the gut microbiota (dysbiosis) has been linked to obesity, insulin resistance, and other metabolic disorders. Innovative therapeutic strategies and dietary interventions aimed at modulating the gut–adipose tissue axis have shown encouraging results in improving metabolic health. A deeper critical understanding of the gut–adipose tissue axis is, therefore, essential in understanding the pathophysiology of metabolic disorders so that targeted interventions can be developed to prevent and treat these metabolic disorders. This article highlights the need for integrative approaches that consider both gastrointestinal and adipose functions in metabolic health management.https://www.mdpi.com/1467-3045/47/6/424gut microbiomeadipose tissueobesitymetabolic healthgut dysbiosisgut–adipose tissue axis |
| spellingShingle | Sanja Borozan Cornelius J. Fernandez Adnan Samee Joseph M. Pappachan Gut–Adipose Tissue Axis and Metabolic Health Current Issues in Molecular Biology gut microbiome adipose tissue obesity metabolic health gut dysbiosis gut–adipose tissue axis |
| title | Gut–Adipose Tissue Axis and Metabolic Health |
| title_full | Gut–Adipose Tissue Axis and Metabolic Health |
| title_fullStr | Gut–Adipose Tissue Axis and Metabolic Health |
| title_full_unstemmed | Gut–Adipose Tissue Axis and Metabolic Health |
| title_short | Gut–Adipose Tissue Axis and Metabolic Health |
| title_sort | gut adipose tissue axis and metabolic health |
| topic | gut microbiome adipose tissue obesity metabolic health gut dysbiosis gut–adipose tissue axis |
| url | https://www.mdpi.com/1467-3045/47/6/424 |
| work_keys_str_mv | AT sanjaborozan gutadiposetissueaxisandmetabolichealth AT corneliusjfernandez gutadiposetissueaxisandmetabolichealth AT adnansamee gutadiposetissueaxisandmetabolichealth AT josephmpappachan gutadiposetissueaxisandmetabolichealth |