Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil
This study aims to perform the first molecular and clinical-epidemiological analysis of dengue cases in Divinopolis, MG, Brazil. Data from 4,110 cases of dengue were accessed and 190 clinical samples were collected for molecular analyses. In this study, 2.7% of the men and 3.0% of the women were adm...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | Journal of Tropical Medicine |
| Online Access: | http://dx.doi.org/10.1155/2014/276912 |
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| author | Juliana Cristina Duarte Braga Leandro César da Silva Jacqueline Domingues Tibúrcio Mirna de Abreu e Silva Lailah Horácio Sales Pereira Karina Rocha Dutra Jaqueline Maria Siqueira Ferreira Débora de Oliveira Lopes Luciana Lara dos Santos |
| author_facet | Juliana Cristina Duarte Braga Leandro César da Silva Jacqueline Domingues Tibúrcio Mirna de Abreu e Silva Lailah Horácio Sales Pereira Karina Rocha Dutra Jaqueline Maria Siqueira Ferreira Débora de Oliveira Lopes Luciana Lara dos Santos |
| author_sort | Juliana Cristina Duarte Braga |
| collection | DOAJ |
| description | This study aims to perform the first molecular and clinical-epidemiological analysis of dengue cases in Divinopolis, MG, Brazil. Data from 4,110 cases of dengue were accessed and 190 clinical samples were collected for molecular analyses. In this study, 2.7% of the men and 3.0% of the women were admitted to hospital. There was no association between gender and hospital admission. The symptoms observed in this study are according to the Health Ministry, but fever was present in 82.2% and not in 100% of cases. The chance of hospital admission was 1.55 higher in patients with any kind of bleeding (334) and 2.4% of individuals without bleeding were also hospitalized due to other warning signs. In the molecular analyses, 23% of the samples were positive for DENV. DENV-2 and DENV-3 were identified in 2010, DENV-3 in 2011, DENV-1 in 2012, and DENV-1 and DENV-4 in 2013. DENV detection was possible in samples with only one day of symptoms. This first report of dengue data in Divinópolis provided more insight into the viral types and effects of disease in the city, confirming the need for caution in assessing cases of suspected dengue and for revision of the criteria proposed by the Health Ministry to classify cases of the disease. |
| format | Article |
| id | doaj-art-8ed0e7fe60b646d788cfd45f8b5fd6a3 |
| institution | OA Journals |
| issn | 1687-9686 1687-9694 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Tropical Medicine |
| spelling | doaj-art-8ed0e7fe60b646d788cfd45f8b5fd6a32025-08-20T02:09:21ZengWileyJournal of Tropical Medicine1687-96861687-96942014-01-01201410.1155/2014/276912276912Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, BrazilJuliana Cristina Duarte Braga0Leandro César da Silva1Jacqueline Domingues Tibúrcio2Mirna de Abreu e Silva3Lailah Horácio Sales Pereira4Karina Rocha Dutra5Jaqueline Maria Siqueira Ferreira6Débora de Oliveira Lopes7Luciana Lara dos Santos8Universidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilSecretaria de Vigilância em Saúde de Divinópolis, Minas Gerais Street, 900 Centro, 35500-007 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilUniversidade Federal de São João del Rei (UFSJ), Avenida Sebastião Gonçalves Coelho, 400 Chanadour, 35501-296 Divinópolis, MG, BrazilThis study aims to perform the first molecular and clinical-epidemiological analysis of dengue cases in Divinopolis, MG, Brazil. Data from 4,110 cases of dengue were accessed and 190 clinical samples were collected for molecular analyses. In this study, 2.7% of the men and 3.0% of the women were admitted to hospital. There was no association between gender and hospital admission. The symptoms observed in this study are according to the Health Ministry, but fever was present in 82.2% and not in 100% of cases. The chance of hospital admission was 1.55 higher in patients with any kind of bleeding (334) and 2.4% of individuals without bleeding were also hospitalized due to other warning signs. In the molecular analyses, 23% of the samples were positive for DENV. DENV-2 and DENV-3 were identified in 2010, DENV-3 in 2011, DENV-1 in 2012, and DENV-1 and DENV-4 in 2013. DENV detection was possible in samples with only one day of symptoms. This first report of dengue data in Divinópolis provided more insight into the viral types and effects of disease in the city, confirming the need for caution in assessing cases of suspected dengue and for revision of the criteria proposed by the Health Ministry to classify cases of the disease.http://dx.doi.org/10.1155/2014/276912 |
| spellingShingle | Juliana Cristina Duarte Braga Leandro César da Silva Jacqueline Domingues Tibúrcio Mirna de Abreu e Silva Lailah Horácio Sales Pereira Karina Rocha Dutra Jaqueline Maria Siqueira Ferreira Débora de Oliveira Lopes Luciana Lara dos Santos Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil Journal of Tropical Medicine |
| title | Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil |
| title_full | Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil |
| title_fullStr | Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil |
| title_full_unstemmed | Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil |
| title_short | Clinical, Molecular, and Epidemiological Analysis of Dengue Cases during a Major Outbreak in the Midwest Region of Minas Gerais, Brazil |
| title_sort | clinical molecular and epidemiological analysis of dengue cases during a major outbreak in the midwest region of minas gerais brazil |
| url | http://dx.doi.org/10.1155/2014/276912 |
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