Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma
Introduction. Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients. There is no efficacious treatment for metastatic disease in this cancer. Identification of markers that can offer prognostic and therapeutic value is a major focus i...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2013/683963 |
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| author | Shawn C. Maloney Bruno F. Fernandes Rafaella Cleto Penteado Emilia Antecka Vasco Bravo-Filho Debra Meghan Sanft Miguel N. Burnier |
| author_facet | Shawn C. Maloney Bruno F. Fernandes Rafaella Cleto Penteado Emilia Antecka Vasco Bravo-Filho Debra Meghan Sanft Miguel N. Burnier |
| author_sort | Shawn C. Maloney |
| collection | DOAJ |
| description | Introduction. Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients. There is no efficacious treatment for metastatic disease in this cancer. Identification of markers that can offer prognostic and therapeutic value is a major focus in this field at present. KAI1 is a metastasis suppressor gene that has been reported to play a role in various human malignancies, although it has not previously been evaluated in UM. Purpose. To investigate the expression of KAI1 in UM and its potential value as a prognostic marker. Materials and Methods. 18 cases of human primary UM were collected and immunostained for KAI1 expression. A pathologist evaluated staining intensity and distribution semiquantitatively. Each case was categorized as group 1 (low staining) or group 2 (high staining). Results. In group 2, two of the 12 cases presented with metastasis. Conversely, in group 1, five out of 6 cases had metastasis. The mean follow-up of patients who did not develop metastasis was 81.81 months (median: 75 months) versus 42.14 months (median: 44 months) for patients with metastasis. Conclusions. KAI1 is a promising candidate marker that may offer prognostic value in UM; it may also represent a therapeutic target in metastatic disease. |
| format | Article |
| id | doaj-art-8eca7811faaa4c9c98e3fed039ccae39 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-8eca7811faaa4c9c98e3fed039ccae392025-08-20T03:37:16ZengWileyJournal of Ophthalmology2090-004X2090-00582013-01-01201310.1155/2013/683963683963Expression of the Metastasis Suppressor KAI1 in Uveal MelanomaShawn C. Maloney0Bruno F. Fernandes1Rafaella Cleto Penteado2Emilia Antecka3Vasco Bravo-Filho4Debra Meghan Sanft5Miguel N. Burnier6The Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaThe Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaThe Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaThe Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaThe Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaThe Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaThe Henry C. Witelson Ocular Pathology Laboratory, McGill University, 3775 University Street, Room 216, Montreal, QC, H3A 2B4, CanadaIntroduction. Uveal melanoma (UM) is an intraocular tumor that leads to metastatic disease in approximately 50% of afflicted patients. There is no efficacious treatment for metastatic disease in this cancer. Identification of markers that can offer prognostic and therapeutic value is a major focus in this field at present. KAI1 is a metastasis suppressor gene that has been reported to play a role in various human malignancies, although it has not previously been evaluated in UM. Purpose. To investigate the expression of KAI1 in UM and its potential value as a prognostic marker. Materials and Methods. 18 cases of human primary UM were collected and immunostained for KAI1 expression. A pathologist evaluated staining intensity and distribution semiquantitatively. Each case was categorized as group 1 (low staining) or group 2 (high staining). Results. In group 2, two of the 12 cases presented with metastasis. Conversely, in group 1, five out of 6 cases had metastasis. The mean follow-up of patients who did not develop metastasis was 81.81 months (median: 75 months) versus 42.14 months (median: 44 months) for patients with metastasis. Conclusions. KAI1 is a promising candidate marker that may offer prognostic value in UM; it may also represent a therapeutic target in metastatic disease.http://dx.doi.org/10.1155/2013/683963 |
| spellingShingle | Shawn C. Maloney Bruno F. Fernandes Rafaella Cleto Penteado Emilia Antecka Vasco Bravo-Filho Debra Meghan Sanft Miguel N. Burnier Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma Journal of Ophthalmology |
| title | Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma |
| title_full | Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma |
| title_fullStr | Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma |
| title_full_unstemmed | Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma |
| title_short | Expression of the Metastasis Suppressor KAI1 in Uveal Melanoma |
| title_sort | expression of the metastasis suppressor kai1 in uveal melanoma |
| url | http://dx.doi.org/10.1155/2013/683963 |
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