Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates

Abstract Condensation and aggregation of disordered proteins in cellular non-equilibrium environments are shaped decisively by enzymes. Enzymes called kinases phosphorylate proteins, consuming the chemical fuel ATP. Protein phosphorylation by kinases such as Casein kinase 1 delta (CK1δ) determines t...

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Bibliographic Details
Main Authors: Emanuele Zippo, Dorothee Dormann, Thomas Speck, Lukas S. Stelzl
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59676-4
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