Synthetic niclosamide-loaded controlled-release nanospheres with high solubility and stability exerting multiple effects against Clostridioides difficile

Synthetic niclosamide-loaded controlled-release nanospheres with high solubility and stability exerting multiple effects against Clostridioides difficile

IntroductionNiclosamide (NIC) has significant potential as a clinical therapeutic agent for Clostridioides difficile infection (CDI); however, its strong hydrophobicity hampers its oral bioavailability, and its active effects against C. difficile remain unclear.MethodsNiclosamide-loaded controlled-r...

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Bibliographic Details
Main Authors: Yulei Tai, Meng Zhang, Yuning Han, Hui Hu, Shan Lin, Fangya Zhai, Menglun Tian, Xiaojun Song, Shuangshuang Wan, Yu Chen, Dazhi Jin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
Subjects:
loaded controlled-release nanospheres
Niclosamide
Clostridioides difficile
spore germination
biofilm formation
multiple effects
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1617631/full
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