Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity
Objective. Obesity is one of the modifiable risk factors for dementia. Insulin resistance, the abundance of advanced glycated end-products, and inflammation are some of the mechanisms associated with the lower cognitive performance observed in obesity. This study aims to evaluate the cognitive funct...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2023/7625720 |
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| author | Jessica M. V. Pino Vitória F. Silva Marcos Mônico-Neto Danielle C. Seva Melissa Y. Kato July N. Alves Gabriela C. Pereira Hanna Karen M. Antunes Thales D. Galvao Lia R. A. Bitterncourt Sergio Tufik Lysien I. Zambrano Ana R. Dâmaso Lila M. Oyama David Thivel Raquel M. S. Campos Kil S. Lee |
| author_facet | Jessica M. V. Pino Vitória F. Silva Marcos Mônico-Neto Danielle C. Seva Melissa Y. Kato July N. Alves Gabriela C. Pereira Hanna Karen M. Antunes Thales D. Galvao Lia R. A. Bitterncourt Sergio Tufik Lysien I. Zambrano Ana R. Dâmaso Lila M. Oyama David Thivel Raquel M. S. Campos Kil S. Lee |
| author_sort | Jessica M. V. Pino |
| collection | DOAJ |
| description | Objective. Obesity is one of the modifiable risk factors for dementia. Insulin resistance, the abundance of advanced glycated end-products, and inflammation are some of the mechanisms associated with the lower cognitive performance observed in obesity. This study aims to evaluate the cognitive function of subjects with distinct degrees of obesity, comparing class I and II obesity (OBI/II) to class III obesity (OBIII), and to investigate metabolic markers that can distinguish OBIII from OBI/II. Study Design. This is a cross-sectional study, in which 45 females with BMI varying from 32.8 to 51.9 kg/m2 completed a set of 4 cognitive tests (verbal paired-associate test, stroop color, digit span, and Toulouse–Pieron cancellation test) and their plasma metabolites, enzymes, and hormones related to glycemia, dyslipidemia, and liver function, as well as the biomarkers of iron status, were concomitantly analyzed. Results. OBIII showed lower scores in the verbal paired-associate test compared to OBI/II. In other cognitive tests, both groups showed similar performance. OBIII presented a lower iron status compared to OBI/II based on total iron binding capacity, degree of transferrin saturation, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin. The levels of indicators for glycemia, liver function, and lipid metabolism were similar in both groups. Analysis of plasma metabolites showed that OBIII had lower levels of pyroglutamic acid, myoinositol, and aspartic acid and higher levels of D-ribose than OBI/II. Conclusion. Iron is an essential micronutrient for several metabolic pathways. Thus, iron dyshomeostasis observed in severe obesity may aggravate the cognitive impairment by altering metabolic homeostasis and enhancing oxidative stress. These findings can contribute to searching for biomarkers that indicate cognitive performance in the population with obesity. |
| format | Article |
| id | doaj-art-8ea9601f33c84fb9b31a38ae3ef5b1c3 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-8ea9601f33c84fb9b31a38ae3ef5b1c32025-02-03T06:43:02ZengWileyInternational Journal of Endocrinology1687-83452023-01-01202310.1155/2023/7625720Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade ObesityJessica M. V. Pino0Vitória F. Silva1Marcos Mônico-Neto2Danielle C. Seva3Melissa Y. Kato4July N. Alves5Gabriela C. Pereira6Hanna Karen M. Antunes7Thales D. Galvao8Lia R. A. Bitterncourt9Sergio Tufik10Lysien I. Zambrano11Ana R. Dâmaso12Lila M. Oyama13David Thivel14Raquel M. S. Campos15Kil S. Lee16Department of BiochemistryDepartment of BiochemistryPost Graduated Program of Interdisciplinary Health SciencesPost Graduated Program of Interdisciplinary Health SciencesDepartment of BiochemistryDepartment of BiochemistryDepartment of BiochemistryPost Graduated Program of Interdisciplinary Health SciencesBariMais Clinic-Integrated MedicineDepartment of PsychobiologyDepartment of PsychobiologyInstitute for Research in Medical Sciences and Right to Health (ICIMEDES)/Scientific Research Unit (UIC), Faculty of Medical Sciences (FCM)Post Graduate Program of NutritionPost Graduate Program of NutritionClermont Auvergne UniversityPost Graduated Program of Interdisciplinary Health SciencesDepartment of BiochemistryObjective. Obesity is one of the modifiable risk factors for dementia. Insulin resistance, the abundance of advanced glycated end-products, and inflammation are some of the mechanisms associated with the lower cognitive performance observed in obesity. This study aims to evaluate the cognitive function of subjects with distinct degrees of obesity, comparing class I and II obesity (OBI/II) to class III obesity (OBIII), and to investigate metabolic markers that can distinguish OBIII from OBI/II. Study Design. This is a cross-sectional study, in which 45 females with BMI varying from 32.8 to 51.9 kg/m2 completed a set of 4 cognitive tests (verbal paired-associate test, stroop color, digit span, and Toulouse–Pieron cancellation test) and their plasma metabolites, enzymes, and hormones related to glycemia, dyslipidemia, and liver function, as well as the biomarkers of iron status, were concomitantly analyzed. Results. OBIII showed lower scores in the verbal paired-associate test compared to OBI/II. In other cognitive tests, both groups showed similar performance. OBIII presented a lower iron status compared to OBI/II based on total iron binding capacity, degree of transferrin saturation, hemoglobin, mean corpuscular volume, and mean corpuscular hemoglobin. The levels of indicators for glycemia, liver function, and lipid metabolism were similar in both groups. Analysis of plasma metabolites showed that OBIII had lower levels of pyroglutamic acid, myoinositol, and aspartic acid and higher levels of D-ribose than OBI/II. Conclusion. Iron is an essential micronutrient for several metabolic pathways. Thus, iron dyshomeostasis observed in severe obesity may aggravate the cognitive impairment by altering metabolic homeostasis and enhancing oxidative stress. These findings can contribute to searching for biomarkers that indicate cognitive performance in the population with obesity.http://dx.doi.org/10.1155/2023/7625720 |
| spellingShingle | Jessica M. V. Pino Vitória F. Silva Marcos Mônico-Neto Danielle C. Seva Melissa Y. Kato July N. Alves Gabriela C. Pereira Hanna Karen M. Antunes Thales D. Galvao Lia R. A. Bitterncourt Sergio Tufik Lysien I. Zambrano Ana R. Dâmaso Lila M. Oyama David Thivel Raquel M. S. Campos Kil S. Lee Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity International Journal of Endocrinology |
| title | Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity |
| title_full | Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity |
| title_fullStr | Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity |
| title_full_unstemmed | Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity |
| title_short | Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity |
| title_sort | severe obesity in women can lead to worse memory function and iron dyshomeostasis compared to lower grade obesity |
| url | http://dx.doi.org/10.1155/2023/7625720 |
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